Live vaccine against tick-borne encephalitis: principles of selection of vaccine strains
Kamalov, I.I.; Sokolova, E.D.; Il' enko, V.I.; Rozhkova, L.V.
Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii 3: 70-76
ISSN/ISBN: 0372-9311 Accession: 002649078
The neurovirulence of clones of the Langat TP-21 and Elantsev strains of the virus of tick-borne encephalitis (TBE) was studied in intra-cerebrally infected monkeys. The neuro-virulence of clones L1, L2 and L3 isolated from Langat TP-21 was lower than that of clones derived from the Elantsev strain, and therefore Langat TP-21 may be retained as a source of clones candidates for the development of a live TBE vaccine. Candidate strains for production of a live TBE vaccine must be significantly less neuro-virulent than the Elantsev strain (used to produce a vaccine that has caused cases of encephalitis in humans) or the vaccine against the yellow fever virus 17D.