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The SAG2 antigen of Toxoplasma gondii and the 31-kDa surface antigen of Sarcocystis muris share similar sequence features


Parasitology Research 81(5): 444-445
The SAG2 antigen of Toxoplasma gondii and the 31-kDa surface antigen of Sarcocystis muris share similar sequence features
In the search for similar cysteine distribution patterns among surface antigens of members of the phylum of Apicomplexa, we found a resemblance between TgSAG2, a 22-kDa surface antigen of Toxoplasma gondii, and the C-terminal half of a 31-kDa surface antigen of Sarcocystis muris, SmSAG1. The overall degree of similarity is low, corresponding to 28% of identity in the 146 amino acids aligned. However, the conservative spacing between the cysteine residues suggest that this similarity might have functional implications. The described amino acid similarity provides a new clue to the molecular relationship between two closely related coccidian parasites.


Accession: 002709379

PMID: 7501647



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