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The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate



The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate



Molecular and Cellular Biology 15(6): 3217-3226



Previous studies have shown that Ig and T cell receptor gene transcriptional enhancers encompass sequences which stimulate V(D)J recombination of associated variable gene segments. To determine whether enhancer-mediated transcriptional activation and recombinational activation depend on the same cis-regulatory sequences, transgenic mice were produced using recombination substratess containing various mutations in the Ig heavy-chain intronic enhancer (E mu ).

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Accession: 002709502

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PMID: 7760817

DOI: 10.1128/mcb.15.6.3217



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