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The antimalarial effect of iron chelators: studies in animal models and in humans with mild falciparum malaria

, : The antimalarial effect of iron chelators: studies in animal models and in humans with mild falciparum malaria. Journal of Inorganic Biochemistry 47(3/4): 267-277

The antimalarial effects of 3-hydroxypyridin-4-ones (CP compounds), a family of bidentate orally effective iron chelators, were explored in experimental animal systems to assess the efficacy of deferoxamine (DF) against human Plasmodium falciparum malaria.

Accession: 002709841

PMID: 1431886

DOI: 10.1016/0162-0134(92)84072-u

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Golenser, J.; Domb, A.; Teomim, D.; Tsafack, A.; Nisim, O.; Ponka, P.; Eling, W.; Cabantchik, Z.I., 1997: The treatment of animal models of malaria with iron chelators by use of a novel polymeric device for slow drug release. The hydrophilic desferrioxamine (DFO) and the lipophilic salicylaldehyde isonicotinoyl hydrazone (SIH) are iron chelators which inhibit in vitro proliferation of Plasmodium falciparum with similar potency (IC50 approximately 20 microM in 24- to 48...

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