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A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice






Proceedings of the National Academy of Sciences of the United States of America 93(11): 5483-5488

A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice

The genetic loci determining dystrophic cardiac calcinosis in an F2 intercross of resistant C57BL/6J and susceptible C3H/HeJ inbred strains were identified. A single major locus, Dyscalc, was found on proximal chromosome 7 in a region syntenic with human chromosome 19q13 and 11p15. The mapping position was confirmed by analysis of B [times] H recombinant inbred strains. The inheritance pattern suggested that this locus affects the susceptibility of cells both to enter necrosis and to then undergo calcification.

Accession: 002738049

PMID: 8643601

DOI: 10.2307/39458

Download PDF Full Text: A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice



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