EurekaMag.com logo
+ Site Statistics
References:
53,517,315
Abstracts:
29,339,501
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice



A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice



Proceedings of the National Academy of Sciences of the United States of America 93(11): 5483-5488



The genetic loci determining dystrophic cardiac calcinosis in an F2 intercross of resistant C57BL/6J and susceptible C3H/HeJ inbred strains were identified. A single major locus, Dyscalc, was found on proximal chromosome 7 in a region syntenic with human chromosome 19q13 and 11p15. The mapping position was confirmed by analysis of B [times] H recombinant inbred strains. The inheritance pattern suggested that this locus affects the susceptibility of cells both to enter necrosis and to then undergo calcification.

Accession: 002738049

Download citation: RISBibTeXText

PMID: 8643601

DOI: 10.2307/39458

Download PDF Full Text: A locus on chromosome 7 determines myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice



Related references

New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice. Physiological Genomics 6(3): 137-144, 2001

A locus on chromosome 7 determines dramatic up-regulation of osteopontin in dystrophic cardiac calcification in mice. American Journal of Pathology 164(4): 1379-1387, 2004

Dystrophic cardiac calcinosis in mice: abnormal myocardial response to freeze-thaw injury. Laboratory Animal Science 40(6): 616-619, 1990

Dystrophic corneal calcification in DBA/2 mice A manifestation of systemic calcinosis. Investigative Ophthalmology & Visual Science 36(4): S1028, 1995

Dystrophic cardiac calcinosis in C3H/HeN mice. Laboratory Animal Science 46(5): 572-575, 1996

Effect of a purified diet on dystrophic cardiac calcinosis in mice. Laboratory Animal Science 38(4): 426-429, 1988

Genetic basis of myocardial cell necrosis and calcification in mice. European Heart Journal 21(Abstract Supplement): 423, August-September, 2000

Dystrophic cardiac calcinosis in mice: genetic, hormonal, and dietary influences. American Journal of Pathology 90(1): 173-186, 1978

Regulatory T cells improve nephrocalcinosis but not dystrophic cardiac calcinosis in DBA/2 mice. American Journal of Pathology 183(2): 382-390, 2013

Chromosomal localization of the loci responsible for dystrophic cardiac calcinosis in DBA/2 mice. Genomics 59(1): 105-107, 1999

Genetic analysis of dystrophic cardiac calcification in DBA/2 mice. Biochemical and Biophysical Research Communications 253(2): 204-208, 1999

Production of dystrophic calcification of cardiac muscle in mice by hydrocortisone. Nature 176(4480): 503-504, 1955

Ultrafine mapping of Dyscalc1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification. Physiological Genomics 28(2): 203-212, 2006

Scrotal calcinosis. Dystrophic calcification of epidermoid cysts. Archives of Dermatology 118(12): 985-988, 1982