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A new approach for the pathogenesis of human African trypanosomiasis

A new approach for the pathogenesis of human African trypanosomiasis

Bulletin de la Societe de Pathologie Exotique 87(5): 319-322

A molecule was isolated from Trypanosoma brucei brucei which triggered the production of IFN- gamma by CD8+ T-cells. IFN- gamma modulates events in the immune and nervous systems of the host, providing a growth stimulus for the parasites. Furthermore, a molecule with IFN- gamma -like immunoreactivity was detected in dorsal root ganglion cells and certain neurons in the brains of rats.

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Accession: 002739066

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PMID: 7496193

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