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A track record of studies on the regulatory mechanism of ornithine decarboxylase. From circadian rhythms to regulated degradation


, : A track record of studies on the regulatory mechanism of ornithine decarboxylase. From circadian rhythms to regulated degradation. Nippon Eiyo Shokuryo Gakkaishi = Journal of the Japanese Society of Nutrition and Food Science 49(1): 1-11

This paper summarizes results of a quarter-century study on the regulatory mechanism of ornithine decarboxylase (ODC), a key enzyme in polyamine synthesis. ODC turns over rapidly and is under negative feedback regulation by polyamines, which accelerate ODC degradation and induce an ODC-inhibitory protein, antizyme. Rat-liver ODC levels exhibit a circadian rhythm with the peak at night, owing to the feeding pattern.

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