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Albumin nitrosylated by activated macrophages possesses antiparasitic effects neutralized by anti-NO-acetylated-cysteine antibodies

Albumin nitrosylated by activated macrophages possesses antiparasitic effects neutralized by anti-NO-acetylated-cysteine antibodies

Journal of Immunology 158(1): 308-314

Activated macrophages exert an L-arginine-dependent cytostatic effect on Trypanosoma musculi. This effect was not observed in the absence of albumin in the culture medium but was restored by the addition of albumin, indicating the presence of an albumin-nitric oxide (NO) adduct acting as an effector molecule. Since L-cysteine represents a privileged target for NO, an immunochemical approach was performed using an acetylated-cysteine-BSA conjugate.

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Accession: 002749777

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PMID: 8977204

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