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Anthelmintic efficacy of soluble formulation of a benzimidazole carbamate a broad spectrum anthelmintic

Anthelmintic efficacy of soluble formulation of a benzimidazole carbamate a broad spectrum anthelmintic

Tropical Medicine 38(1): 13-20

Methyl-(5-((4-(2-pyridinyl)-1-piperazinyl)-carbonyl-1H-benzimidazol-2-yl)-carbamate (CDRI Compound 81/470) has consistently exhibited broad-spectrum anthelmintic efficacy both against adult and larval stages of various helminth parasites of experimental and domestic animals, by oral and parenteral routes. The compound incorporated in transdermal tapes has also yielded anthelmintic action. With a view to enhance absorption and consequently the efficacy, a soluble formulation of the compound has been developed and its efficacy was evaluated against various experimental helminth parasites of rodents (Ancylostoma ceylanicum (adult), Nippostrongylus brasiliensis (adult and L-4), Syphacia obvelata (adult)) and poultry (Ascaridia galli). This appears to be the only benzimidazole which could be solubilized. While the soluble formulation has been found to have comparable efficacy to the powder form against intestinal worms, the efficacy was substantially increased against systemic parasites (N. brasiliensis L-4 stage). The enhanced efficacy by oral route is very well correlated with high absorption of drug from soluble formulation which has been demonstrated by the pharmacokinetic studies reported by Nagaraja et al. (1995). The results of the present study suggest that the soluble formulation may find wider application in respect to easy administration through drinking water in large herds, flocks and also against tissue dwelling parasites specially filarids.

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