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Bcl-2 alters the antigen-driven selection of B cells in micro kappa but not in micro -only Xid transgenic mice


, : Bcl-2 alters the antigen-driven selection of B cells in micro kappa but not in micro -only Xid transgenic mice. Journal of Immunology Baltimore 157(3): 1054-1061

A point mutation in the pleckstrin homology domain of the mouse Bruton's tyrosine kinase (btk) gene results in an X-linked immune defect, Xid, characterized by immunological unresponsiveness to polymeric carbohydrate antigens. In Xid mice, B cells specific for phosphocholine do not develop in peripheral lymphoid tissues because they either fail to be positively selected from the marrow or they are clonally deleted via an antigen-driven, receptor-mediated process.

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