EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Behavioral effects of estrogen receptor gene disruption in male mice


, : Behavioral effects of estrogen receptor gene disruption in male mice. Proceedings of the National Academy of Sciences of the United States of America 94(4): 1476-1481

Gonadal steroid hormones regulate sexually dimorphic development of brain functions and behaviors. Their nuclear receptors offer the opportunity to relate molecular events in neurons to simple instinctive mammalian behaviors. We have determined the role of estrogen receptor (ER) activation by endogenous estrogen in the development of male-typical behaviors by the use of transgenic estrogen-receptor-deficient (ERKO) mice. Surprisingly, in spite of the fact that they are infertile, ERKO mice showed normal motivation to mount females but they achieved less intromissions and virtually no ejaculations. Aggressive behaviors were dramatically reduced and male-typical offensive attacks were rarely displayed by ERKO males. Moreover, ER gene disruption demasculinized open-field behaviors. In the brain, despite the evident loss of functional ER protein, the androgen-dependent system appears to be normally present in ERKO mice. Together, these findings indicate that ER gene expression during development plays a major role in the organization of male-typical aggressive and emotional behaviors in addition to simple sexual behaviors.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 002763481

PMID: 9037078

DOI: 10.2307/41356

PDF Full Text: Behavioral effects of estrogen receptor gene disruption in male mice


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Ede, Hüseyin.; Erkoç, M.Fatih.; Okur, A.; Erbay, A.Rıza., 2015: Impaired aortic elasticity and diastolic functions are associated with findings of coronary computed tomographic angiography. Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Aortic elasticity and diastolic functions are helpful parameters in assessment of CAD. In this study we aimed to learn whether diastolic function and aortic e...

Hansson, A., 1953: The interaction between heredity and plane of nutrition during rearing with reference to the growth, milk yield and life span of cows. Three preliminary experiments are briefly sketched, which were designed to investigate the effect of plane of nutrition during early growth on the variables listed. These experiments showed that plane of nutrition affected chiefly the speed of gro...

Flagg, T.P.; Tate, M.; Welling, P.A., 1998: A Bartters mutation in Kir 11a alters K channel function by dominant negative effects. Journal of the American Society of Nephrology 9(PROGRAM AND ABSTR ISSUE): 34A, Sept

Solenthaler, M.; Ritter, M.; Candinas, R.; Jenni, R.; Amann, F.W., 1994: Arrhythmogenic right ventricular dysplasia in identical twins. American Journal of Cardiology 74(3): 303-304

David, J-Stephane.; Tousignant, C.P.; Bowry, R., 2006: Tricuspid annular velocity in patients undergoing cardiac operation using transesophageal echocardiography. The complex geometry of the right ventricle (RV) and poor endocardial definition make quantitative assessment of RV function difficult. Doppler tissue imaging may be helpful in quantifying RV function through measurement of tricuspid annular veloc...

Patil, D.R.; Patil, H.B.; Prashanth, J.M.; Patil, S.N., 2005: Studies on the integrated nutrient management strategies for higher productivity in mango cv. alphonso. Karnataka Journal of Agricultural Sciences 18(3): 862-864

Fox, R. C., 1977: Notes on the dentition and relationships of the late Cretaceous insectivore Gypsonictops Simpson. Canadian J Earth Sci, 148: 1823-1831, illust.

RUDMAN.D.; REID.M.B.; SEIDMAN.F.; D.G.ROLAMO.M.; WERTHEIM.A.R.; BERN.S., 1961: Purification and properties of a component of the pituitary gland which produces lipemia in the rabbit. A modification of the previously described method for the preparation of Fraction H from hog pituitary glands by alkaline extraction, fractional precipitation with acetone, and chromatography on IRC-50 resin is presented. The yield is 8 mg. per gr...

Lovell, K.L.; Mitchell Herpolsheimer, C.; Ames, N.K.; Snyder, E.Y.; Anson, D.; Kraemer, S.; Jones, M.Z., 1997: Prenatal xenografts of murine multipotent neural precursor cells overexpressing beta-mannosidase as a therapeutic approach in caprine beta-mannosidosis. Brain Pathology 7(4): 1371

Viswanathan, K.; Lakshmanan, K.K., 1986: Histochemistry and in vitro study on the pollinium of calotropis gigantea r. br. An integrated account of the morphology, anatomy, in vitro germination, polarity, viability and histochemistry of the pollinium of Calotropis gigantea is presented. The pollinium exhibits uniform pattern and organisation with the pollen grains dis...