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Behavioral studies on alkaloids extracted from the leaves of Hunteria zeylanica


, : Behavioral studies on alkaloids extracted from the leaves of Hunteria zeylanica. Biological & Pharmaceutical Bulletin 19(3): 394-399

The effects of a crude methanol extract, butanol- and chloroform-fractions, and a pure compound, corymine, extracted from the leaves of H. zeylanica on locomotor activity and rearing, pentobarbital-induced sleep, and drug-induced convulsions were studied in mice. The methanol extract dose-dependently decreased rearing without a significant effect on locomotor activity at doses of 15, 60 and 120 mg/kg. It did not significantly prolong the sleeping time but potentiated the convulsions induced by strychnine, but not that by either picrotoxin or pentylenetetrazole, at a dose of 120 mg/kg. The butanol-fraction significantly prolonged sleeping time at a dose of 125 mg/kg but did not affect either of the convulsive drugs. The chloroform fraction prolonged sleeping time at doses of 62.5 and 125 mg/kg and potentiated the convulsions induced by either strychnine or picrotoxin, but not that by pentylenetetrazole, at doses of 15, 30, 60 and 120 mg/kg. Corymine did not significantly prolong sleeping time, but potentiated the convulsions induced by either strychnine or picrotoxin, not by pentylenetetrazole, at doses of 2, 8 and 15 mg/kg. These results suggest that crude alkaloidal extracts of H. zeylanica leaves produce biphasic effects on the central nervous system (CNS), depression and stimulation, while the pure compound, corymine, has a unique central stimulatory effect in mice.


Accession: 002763511

PMID: 8924908

DOI: 10.1248/bpb.19.394

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Related references

Leewanich, P.; Tohda, M.; Matsumoto, K.; Subhadhirasakul, S.; Takayama, H.; Watanabe, H., 1996: Behavioral studies of alkaloids extracted from the leaves of Hunteria zeylanica. The effects of a crude methanol extract, butanol- and chloroform-fractions, and a pure compound, corymine, extracted from the leaves of H. zeylanica on locomotor activity and rearing, pentobarbital-induced sleep, and drug-induced convulsions were...

Reanmongkol, W.; Matsumoto, K.; Watanabe, H.; Subhadhirasakul, S.; Sakai, S., 1994: Antinociceptive and antipyretic effects of alkaloids extracted from the stem bark of Hunteria zeylanica. Effects of crude alkaloids extracted from the stem bark of Hunteria zeylanica GARD. (H. zeylanica) on nociceptive responses, capillary permeability, yeast-induced hyperthermia, pentobarbital-induced sleep, and spontaneous motor activity were inves...

Reanmongkol, W.; Matsumoto, K.; Tohda, M.; Watanabe, H.; Subhadhirasakul, S.; Takayama, H.; Sakai, S.I.hiro, 1995: Antinociceptive, antipyretic and anti-inflammatory effects of alkaloids extracted from Hunteria zeylanica. Japanese Journal of Pharmacology 67(SUPPL 1): 282P

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Takayama, H.; Subhadhirasakul, S.; Mizuki, J.; Kitajima, M.; Aimi, N.; Ponglux, D.; Sakai, S.I.hiro, 1994: A new class of two dimeric indole alkaloids, coryzeylamine and deformylcoryzeylamine, from the leaves of Hunteria zeylanica in Thailand. Two novel dimeric indole alkaloids, coryzeylamine (2) and deformylcoryzeylamine (3), which are composed of sarpagine-type and echitamine-type monoterpenoid indole alkaloids, were isolated from the leaves of Hunteria zeylanica native to Thailand.

Reanmongkol, W.; Subhadhirasakul, S.; Kongsang, J.; Tanchong, M.; Kitti, J., 2000: Analgesic and Antipyretic Activities of n-Butanol Alkaloids Extracted from the Stem Bark Hunteria Zeylanica and its Major Constituent, Strictosidinic Acid, in Mice. The pharmacological activities of the n -butanol alkaloids extracted from the stem bark of Hunteria zeylanica (Retz) Gardn. ex Thw. ( H. zeylanica ) and its major constituent, strictosidinic acid, on nociceptive response using writhing and hot pla...

Lavaud C.; Massiot G.; Vercauteren J.; L.M.n Olivier L., 1982: Alkaloids of hunteria zeylanica. Twenty alkaloids were isolated from the leaves and stem bark of H. zeylanica, collected in Kenya. They were 3-epi-dihydrocorymine 3-acetate, norisocorymine, corymine, 3-epi-dihydrocorymine 17-acetate, picralinal, picrinine, 3-epi-dihydrocorymine,...

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Liu, Q.; Chen, C-Jun.; Zhang, L.; Gao, K., 2016: Two new indole alkaloids from Hunteria zeylanica. Two new indole alkaloids, 14β-hydroperoxy-eburnamine (1) and 18α-hydroxy-eburnamine (2), together with three known indole alkaloids, (-)-eburnamonine (3), (-)-eburnamenine (4), and eburnamine (5) were isolated from Hunteria zeylanica collected i...