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Beneficial effects of S-113m, a novel herbal prescription, on learning impairment model in mice


, : Beneficial effects of S-113m, a novel herbal prescription, on learning impairment model in mice. Biological & Pharmaceutical Bulletin 18(11): 1498-1503

The effects of S-113m, a novel herbal prescription consisting of Biota orientalis, Panax ginseng and Schisandra chinensis, were studied regarding learning and memory performance in the step-down and lever-press tests in normal, as well as in learning-impaired, mice. The prescription had no effect on memory registration, consolidation and retrieval processes or on motor activity in normal mice. However, a single oral administration of S-113m at doses of 250 and 500 mg/kg reduced the ethanol-induced and scopolamine-induced impairment of memory registration in the step-down test. The preparation also improved the electroconvulsive shock-induced impairment of memory consolidation in the same test. S-113m did not, however, attenuate the ethanol-induced impairment of memory retrieval. These results suggest that S-113m has a preferential beneficial effect on the impairment of memory registration and memory consolidation rather than on memory retrieval in mice, through direct action on the learning and memory processes.

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Accession: 002763805

PMID: 8593466

DOI: 10.1248/bpb.18.1498

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