Biometrical genetic analysis of serum cholesterol response and basal serum HDL cholesterol level in the rabbit
Lith, H.A. van; Lankhorst, A.; Bieman, M.D.; Versluis, A.; Boere, H.A.G.; Zutphen, L.F.M. van
Scandinavian Journal of Laboratory Animal Science 23(2): 79-85
Basal high density lipoprotein (HDL) cholesterol of rabbits, and their serum cholesterol response to a high-cholesterol diet, were measured in crosses between hyper-responding and hypo-responding inbred strains. It was shown that 30% of the individual variation in serum cholesterol response is under genetic control, and that 10-16 loci may be involved. The hsuperscript 2 of the basal HDL cholesterol concentration was 0.50-0.80.