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Characterization and performance of a new direct compression excipient for chewable tablets: XylitabReg.



Characterization and performance of a new direct compression excipient for chewable tablets: XylitabReg.



Drug Development and Industrial Pharmacy 22(9/10): 925-932



A series of granular excipients for direct compression is available from American Xyrofin: Xylitab 300 is pure granulated xylitol; Xylitab 200 contains 1.5% Na-CMC, and Xylitab 100 contains 3% polydextrose. Xylitab 200 and Xylitab 100 were evaluated for compaction, flow, lubrication requirements and dilution potential. As expected, the products required lubrication for tableting; inclusion of 0.5% magnesium stearate + 0.5% stearic acid gave the best performance.

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