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Characterization of an extract from the leaves of Cissampelos sympodialis Eichl. on the spontaneous tone of isolated trachea



Characterization of an extract from the leaves of Cissampelos sympodialis Eichl. on the spontaneous tone of isolated trachea



Phytotherapy Research 11(7): 496-499



An aqueous fraction of the ethanol extract of leaves of C. sympodialis (collected from Brazil) relaxed the spontaneous tone of guineapig tracheal smooth muscle rings (IC<sub>50</sub> value of 20.5 micro g/ml). The fraction inhibited cyclic nucleotide phosphodiesterase activity in isolated smooth muscle homogenates and stimulated an increase in intracellular cAMP synthesis in intact cultured smooth muscle cells.

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Accession: 002775476

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DOI: 10.1002/(sici)1099-1573(199711)11:7<496::aid-ptr137>3.0.co;2-7


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