+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Characterization of antineutrophil antibodies in patients with neutropenia associated with nutritional copper deficiency



Characterization of antineutrophil antibodies in patients with neutropenia associated with nutritional copper deficiency



Acta Haematologica 94(4): 192-195



Six antineutrophil antibody (ANA)-positive patients with copper deficiency were classified into two groups; those with (group A, n = 3) and those without (group B, n = 3) neutropenia. The percent binding of ANA for normal peripheral neutrophils was similar in both groups (83.5 +/- 7.2 vs. 79.1 +/- 10.5%). The percent binding of sera to cultured promyelocytic leukemia cells (HL-60) was increased in group A (from 3.7 +/- 3.2 to 12.2 +/- 2.3%) but not in group B (from 65.3 +/- 21.7 to 40.7 +/- 6.3%) after stimulation of HL-60 with DMSO. The stimulated HL-60 cells expressed CD 16 and CD 11b antigens. In the presence of monoclonal antibody for CD 16, the titer of ANA was nil in group A and unchanged in group B. Thus, ANA of patients with neutropenia may recognize mainly the CD 16 antigen, the Fc gamma receptor III of neutrophils.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 002775496

Download citation: RISBibTeXText

PMID: 8610476

DOI: 10.1159/000204008


Related references

Detection of antineutrophil antibodies in patients with neutropenia in infancy. Japanese Journal of Clinical Hematology 30(5): 663-667, 1989

Anti-neutrophil antibodies in patients with nutritional copper deficiency. European Journal of Pediatrics 150(5): 327-330, 1991

Lack of relation of granulocyte antibodies (antineutrophil antibodies) to neutropenia in children with human immunodeficiency virus infection. Pediatric Infectious Disease Journal 16(9): 881-884, 1997

Idiopathic neutropenia antineutrophil antibodies and clinical correlations. American Journal of Medicine 90(2): 211-216, 1991

Antineutrophil cytoplasmic antibodies, autoimmune neutropenia, and vasculitis. Seminars in Arthritis and Rheumatism 41(3): 424-433, 2011

Nutritional copper deficiency in severely handicapped patients on a low copper enteral diet for a prolonged period: estimation of the required dose of dietary copper. Journal of Pediatric Gastroenterology and Nutrition 7(4): 583-587, 1988

Are antineutrophil antibodies in children with HIV infection causally related to neutropenia?. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 36: 200, 1996

Significance of the detection of antineutrophil antibodies in children with chronic neutropenia. Blood 99(9): 3468-3471, 2002

Significance of the quantification of antineutrophil antibodies in children with chronic neutropenia. Blood 98(11 Part 1): 229a, 2001

Autoimmune neutropenia due to antineutrophil antibodies in a patient with primary sclerosing cholangitis. Clinical Journal of Gastroenterology 3(3): 149-154, 2010

Chronic idiopathic neutropenia. A cytofluorimetric method to detect antineutrophil antibodies. Recenti Progressi in Medicina 95(3): 144-148, 2004

The severity of immune neutropenia correlates with the maturational specificity of antineutrophil antibodies. British Journal of Haematology 58(2): 209-216, 1984

Anemia and neutropenia in elderly patients caused by copper deficiency for long-term enteral nutrition. Japanese Journal of Clinical Hematology 35(11): 1276-1281, 1994

Antineutrophil cytoplasmic antibodies in Bulgarian patients with rheumatoid arthritis: characterization and clinical associations. Rheumatology International 26(2): 107-114, 2005

Antibiotic-induced severe neutropenia with multidrug-dependent antineutrophil antibodies developed in a child with Streptococcus pneumoniae infection. Journal of Korean Medical Science 24(5): 975-978, 2009