+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Characterization of lymphocyte subtypes in scabietic skin lesions of naive and sensitized dogs



Characterization of lymphocyte subtypes in scabietic skin lesions of naive and sensitized dogs



Veterinary Parasitology 68(4): 347-358



We delineated the density of cells expressing CD4, CD8, CD21 and CD45RA antigens in the cellular infiltrates in the epidermis, dermis and follicular epithelium in scabietic skin lesions of naive hosts and sensitized hosts that expressed resistance to scabies infestation. No cells expressing CD21 (B-lymphocytes and follicular dendritic cells) were present in the epidermis and only a few were occasionally present in the dermis during both the first and second infestations. Naive T-cells (CD45RA+) and CD8+ cells (cytotoxic and suppressor T-lymphocytes) were present in varying densities in the infiltrates throughout the epidermis, dermis and follicular epithelium with no apparent differences in density and the rate of appearance between sensitizing and challenge infestations. CD4+ cells were abundant in fluctuating densities in the dermis, epidermis, and follicular epidermis during the sensitizing infestation and these cells became the dominant cell type early during the challenge infestation. The density of CD4+ cells in the infiltrate was much greater during the challenge than during the sensitization infestation. This population of CD4+ cells consisted of both T-helper/inducer cells and neutrophils and the large increase in their numbers during the challenge suggested they played a key role in the successful immune/inflammatory response that resulted in resistance to scabies infestation.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 002775771

Download citation: RISBibTeXText

PMID: 9106956

DOI: 10.1016/s0304-4017(96)01093-x


Related references

Characterization of antigen presenting cells and T-cells in progressing scabietic skin lesions. Veterinary Parasitology 67(3-4): 247-258, 1996

Patch testing of experimentally sensitized beagle dogs: development of a model for skin lesions of atopic dermatitis. Veterinary Dermatology 17(2): 95, 2006

Studies on lymphocyte reaction in skin allograft. 2. Accelerated rejection of skin allograft by transfer of sensitized lymph node cells. Nihon Geka Hokan. Archiv für Japanische Chirurgie 39(1): 38-44, 1970

Strongyloides ratti: studies of cutaneous reactions elicited in naive and sensitized rats and of changes in surface antigenicity of skin-penetrating larvae. Parasitology 98: 95, 1989

Tissue typing by unidirectional mixed lymphocyte culture. II. The relationship of in vitro lymphocyte compatibility to skin allograft rejection in dogs. Acta Medicinae Okayama 24(6): 597-602, 1970

Isolation, characterization and drug sensitivity of coagulase-positive staphylococci (Staphylococcus aureus and intermedius) from dogs with skin lesions in the Londrina region. Semina, Medicina Veterinaria 7: 34-37, 1986

Down-regulation of lymphocyte adrenoceptor subtypes in dogs affected by dilated cardiomyopathy. Journal of Veterinary Pharmacology & Therapeutics 20(Suppl. 1): 236-237, 1997

Tissue typing by uni directional mixed lymphocyte culture part 3 the relationship of in vitro lymphocyte compatibility to skin allo graft rejection in dogs. Acta Medica Okayama: 597-602, 1970

The development of pulmonary lesions associated with dead adult D. immitis in naive dogs. Journal of Veterinary Medicine Series B 40(3): 197-205, 1993

The effect of a goat anti dog sensitized lymphocyte serum on kidney allo graft survival in dogs. European Surgical Research 2(2): 140-141, 1970

Histological characterization of the distribution of mast cell subtypes within the airways of sensitized guinea-pigs. Journal of Pharmacy & Pharmacology 51(Suppl. ): 143, 1999

Lymphocyte subtypes in experimentally induced early-stage bovine tuberculous lesions. Journal of Comparative Pathology 124(1): 46-51, 2001

Studies on contact skin reactions and normal skin of passively sensitized guinea-pigs. I. A histological study of test lesions in recipients after passive transfer of dinitrochlorobenzene hypersensitivity with lymphoid cells. Acta Soc Med Upsal 68(5/6): 193-214, 1963

Determination and comparison of serum zinc values in healthy dogs and dogs with skin lesions. Veteriner Fakultesi Dergisi, Uludag Universitesi 15(1/2/3): 197-202, 1996

Studies on Contact Skin Reactions and Normal Skin of Passively Sensitized Guinea-Pigs. I. a Histological Study of Test Lesions in Recipients After Passive Transfer of Dinitrochlorobenzene (Dncb) Hypersensitivity with Lymphoid Cells. Acta Societatis Medicorum Upsaliensis 68: 193-214, 1963