+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice

Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice

Journal of Virology 71(1): 9-16

Insertional mutagenesis with Moloney murine leukemia virus (MoMLV) in c-myc and Pim-1 transgenic mice permits the identification of oncogenes that collaborate with the transgenes in lymphomagenesis. The recently identified common insertion site pal-1, in MoMLV-induced lymphomas, is located in a region in which several independent integration clusters are found: eis-1, gfi-1, and evi-5. Proviral insertions of MoMLV in the different integration clusters upregulate the transcriptional activity of the Gfi-1 gene, which is located within the pal-1 locus. The eis-1/pal-1/gfi-1/evi-5 locus serves as a target for MoMLV proviral insertions in pre-B-cell lymphomas of E-mu-myc transgenic mice (20%) and in T-cell lymphomas of H-2K-myc (75%) and E-mu-pim-1 (93%) transgenic mice. Many tumors overexpress both Gfi-1 as well as Myc and Pim gene family members, indicating that Gfi-1 collaborates with Myc and Pim in lymphomagenesis. Proviral integrations in the previously identified insertion site bmi-1 are, however, mutually exclusive with integrations in the eis-1/pal-1/gfi-1/evi-5 locus. This finding suggests that Bmi-1 and Gfi-1 belong to the same complementation group in lymphoid transformation.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 002775848

Download citation: RISBibTeXText

PMID: 8985317

Related references

The Icsbp locus is a common proviral insertion site in mature B-cell lymphomas/plasmacytomas induced by exogenous murine leukemia virus. Virology 352(2): 306-318, 2006

til-1: a novel proviral insertion locus for Moloney murine leukaemia virus in lymphomas of CD2-myc transgenic mice. Journal of General Virology 77: 443-446, 1996

A coordinated proto oncogene expression characterizes mcf 247 murine leukemia virus induced t cell lymphomas irrespective of proviral insertion affecting myc loci. Leukemia Research 14(6): 549-558, 1990

Common proviral integration region on mouse chromosome 7 in lymphomas and myelogenous leukemias induced by Friend murine leukemia virus. Journal of Virology 57(2): 526-533, 1986

Second-site proviral enhancer alterations in lymphomas induced by enhancer mutants of SL3-3 murine leukemia virus: negative effect of nuclear factor 1 binding site. Journal of Virology 71(2): 1196-1206, 1997

Comparison of endogenous murine leukemia virus proviral organization and rna expression in 3 methylcholanthrene induced and spontaneous thymic lymphomas in rf and akr mice. Journal of Virology 53(1): 94-99, 1985

Identification and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus. Proceedings of the National Academy of Sciences of the United States of America 87(4): 1332-1336, 1990

Proviral activation of the putative oncogene pim 1 in murine leukemia virus induced t cell lymphomas. EMBO (European Molecular Biology Organization) Journal 4(7): 1793-1798, 1985

Infection of WHV/c-myc transgenic mice with Moloney murine leukaemia virus and proviral insertion near the syndecan-4 gene in an early liver tumour. Research In Virology. 149(3): 133-143, E, 1998

Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. Journal of Medicinal Chemistry 48(24): 7604-7614, 2005

Influence of murine leukemia proviral integrations on development of N-methyl-N-nitrosourea-induced thymic lymphomas in AKR mice. Journal of Virology 65(11): 5751-5756, 1991

Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas. Embo Journal 8(3): 743-748, 1989

Identification of a common site of provirus integration in radiation leukemia virus-induced T-cell lymphomas in mice. Virology 264(1): 181-186, 1999

Non-identical patterns of proviral insertions around host transcription units in lymphomas induced by different strains of murine leukemia virus. Virology 353(1): 193-199, 2006

Common proviral integration sites in C57BL mouse lymphomas induced by radiation leukemia virus and absence of novel virus-related sequences in radiogenic lymphoma DNA. Leukemia Research 6(3): 285-297, 1982