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Characterization of the action on central opioid receptors of furaneudesma-1,3-diene, a sesquiterpene extracted from myrrh

Dolara, P.; Moneti, G.; Pieraccini, G.; Romanelli, N.

Phytotherapy Research 10(Suppl 1): S81-S83

1996

ISSN/ISBN: 0951-418X
Accession: 002776029
Myrrh, a resin extracted from north African shrubs of the genus Commiphora, is used as a perfume and as a remedy for human and animal diseases. Three furanosesquiterpenoids (curzarene, furanoeudesma-1,3-diene and furanodiene) were isolated from the hexane extract of commercially available myrrh (C. molmol). Furanoeudesma-1,3-diene and curzarene (2.5 mg/kg, intracerebroventricular route) exhibited analgesic properties in the hot plate test in mice.

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Claeson, P.A.dersson, R.S.muelsson, G. 1990: T-cadinol: a sesquiterpene with smooth muscle relaxing and antidiarrhoeal properties isolated from scented myrrh Planta medica 56(6): 685
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Scheurer, U.; Drack, E.; Halter, F. 1990: Motor effects of a novel drug with potent antinociceptive action and high affinities to cerebral opioid receptors dopamine d 1 receptors and 5 ht 1 receptors cy 208 243 on the rat colon in vitro Gastroenterology 98(5 Part 2): A388
Ji, G.; Neugebauer, V. 2020: Kappa opioid receptors in the central amygdala modulate spinal nociceptive processing through an action on amygdala CRF neurons Molecular Brain 13(1): 128
Kaloustian, K.V. 1988: Studies on opioid receptors and the action of opioid peptides on gut contraction and body weight in the earthworm lumbricus terrestris AAAS (American Association for the Advancement of Science) Publication (88-30): 204
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Jones, D.N.C.; Holtzman, S.G. 1992: Evidence for the involvement of central delta opioid receptors in the interaction between opioid antagonists and amphetamine British Journal of Pharmacology 105(Proceedings Suppl APRIL): 40P
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