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Cytoprotective effect of phenolics from Colchicum on rat hepatocytes



Cytoprotective effect of phenolics from Colchicum on rat hepatocytes



Fitoterapia 66(5): 399-402



The phenolic composition of the aerial parts and corms of C. bornmuelleri, C. kotschyi, C. macrophyllum and C. speciosum were analysed by capillary GC or GC-MS and twenty-three phenolics were identified. The phenolic fractions were tested for their cytoprotective effect on tBH-induced injury on isolated rat hepatocytes. The results indicate that phenolic fractions from leaves and flowers and the main constituent luteolin reduced the tBH-induced LPX and leakage of LDH. In contrast, phenolic fractions from seeds, not containing luteolin, had no significant effect on LDH though a decrease in LPx was observed.

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