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Development of stable formulation of Picroliv, a new hepatoprotective agent






Indian Journal of Pharmaceutical Sciences 57(2): 88-90

Development of stable formulation of Picroliv, a new hepatoprotective agent



Accession: 002800103



Related references

Dhawan, B.N., 1995: Picroliv-a new hepatoprotective agent from an Indian medicinal plant, Picrorhiza kurroa. Medicinal Chemistry Research 5(8): 595-605

Sethi N.; Singh R.K.; Sinha N.; Bhatia G.S.; Srivastava S.; Roy A.K., 1991: Safety evaluation studies on a new hepatoprotective agent picroliv in rats and monkeys. The effect of 90 days oral administration of a new hepatoprotective agent 'Picroliv' was carried out in rats and monkeys. None of the toxicity parameters-general observable behaviour, growth rate, haemogram, biochemistry and histopatholo...

Jain A.K.; Sethi N., 1992: Effect of picroliv a hepatoprotective agent prepared from picrorhiza kurroa on mice chromosomes. Picroliv, a hepatoprotective agent prepared from P. kurroa, was assayed for its effects on mice chromosomes in bone marrow cells. Treatment of mice with 0.1, 1.0 and 10.0 mg/kg b.w. per os did not enhance the magnitude of chromosomal aberrations a...

Fitzpatrick, S.; Taylor, S.; Booth, S.W.; Newton, M.J., 2006: The development of a stable, coated pellet formulation of a water-sensitive drug, a case study: development of a stable core formulation. A development program has been carried out to provide a stable extrusion/spheronisation pellet formulation for a highly water-soluble drug, sitagliptin, which undergoes a change in physical form on processing and is subject to hydrolytic decomposi...

Saraswat, B.; Visen, P.K.S.; Patnaik, G.K.; Dhawan, B.N., 1997: Hepatoprotective effect of picroliv against rifampicin-induced toxicity. Picroliv, the active constituent of the plant Picrorhiza Kurroa, showed significant hepatoprotective as well as anticholestatic activity against rifampicin-induced hepatic damage. Rifampicin (50 mg/kg ip times 6 days) resulted in the reduction of...

Tripathi, B., K.; Srivastava, A., K., 2004: Hepatoprotective effects of picroliv in alcohol-fed albino rats. Alcohol abuse is thought to be a risk factor for the cause of liver damage, hyperlipidemia and insulin resistance. An alcohol-fed rat model was developed by chronic administration of ethanol to rats which caused significant alteration in liver fun...

Shukla, B.; Visen, P.K.; Patnaik, G.K.; Dhawan, B.N., 1991: Choleretic effect of picroliv, the hepatoprotective principle of Picrorhiza kurroa. Picroliv, the hepatoprotective principle of the plant Picrorhiza kurroa, showed a dose-dependent (1.5-12 mg/kg .times. 7) choleretic effect in conscious rats and anaesthetized guinea pigs. It also possessed a marked anticholestatic effect against...

Tripathi S.C.; Patnaik G.K.; Dhawan B.N., 1991: Hepatoprotective activity of picroliv against alcohol carbon tetrachloride induced damage in rat. 1. The hepatoprotective activity of picroliv, the active standardised fraction of Picrorhiza kurrooa, was evaluated against alcohol-CCl4 induced liver damage in the rat at the doses of 3, 6 and 12 mg/kg/day, p.o. for 7 days. 2. It showed a signifi...

Tripathi, B.K.; Srivastava, A.K., 2003: Hepatoprotective, dyslipidemic and insulin resistance reversal effects of picroliv in alcohol-fed rats. Medicinal Chemistry Research 12(4-5): 263

Dwivedi, Y.; Rastogi, R.; Chander, R.; Sharma, S.K.; Kapoor, N.K.; Garg, N.K.; Dhawan, B.N., 1990: Hepatoprotective activity of picroliv against carbon tetrachloride-induced liver damage in rats. Administration of carbon tetrachloride to normal rats increased activities of hepatic 5(1)-nucleotidase, acid phosphatase, acid ribonuclease while the activities of succinate dehydrogenase, glucose 6-phosphatase, superoxide dismutase and cytochrom...