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Effect of chronic trypanosomiasis on the bioavailability of alpha -difluoromethylornithine (DFMO) after oral administration: pharmacokinetics study on DFMO plasma levels in infected and noninfected mice using a high-performance liquid chromatography assay






Parasitology Research 83(4): 386-389

Effect of chronic trypanosomiasis on the bioavailability of alpha -difluoromethylornithine (DFMO) after oral administration: pharmacokinetics study on DFMO plasma levels in infected and noninfected mice using a high-performance liquid chromatography assay

A method for detecting alpha -difluoromethylornithine (DFMO) in plasma during pharmacokinetic studies in mice is described, using conventional reversed-phase HPLC with UV detection. It was shown that mice infected with Trypanosoma brucei had Cmax values 2-fold higher than those of non-infected mice. It is concluded that pharmacokinetic studies should compare both infected and naive subjects.


Accession: 002811061

PMID: 9134564



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