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Effect of dietary corticosterone on mononuclear cells proliferation to mitogen in spleen and thymus of broiler chicks


Animal Science & Technology 67(2): 160-164
Effect of dietary corticosterone on mononuclear cells proliferation to mitogen in spleen and thymus of broiler chicks
Proliferative responses of mononuclear cell (MNC) in spleen and thymus to concanavalin A were investigated in chicks fed diets supplemented with 0 or 10 ppm corticosterone ad libitum for 10 days. When autologous serum was added to the culture medium at 5% of final volume, dietary corticosterone reduced the proliferative response of MNC in thymus, but not in spleen. The mitogenic response of splenocyte MNC obtained from the control-chicks was reduced by the addition of the serum obtained from chicks fed corticosterone, but the response of splenocyte MNC from chicks fed corticosterone did not differ from that of the control, regardless of serum sources. The results suggest that dietary corticosterone efficiently reduces the proliferative response of MNC in thymus to Con A rather than those in spleen. and may not impair, at least, capacity of Con A induced proliferative response of splenocyte in male broilers.


Accession: 002811715



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