Effect of hexachlorophene on in vitro mortality and some enzyme systems of swine kidney worm Stephanurus dentatus

Kaushal, P.; Majumdar, S.; Singh, K.; Agarwal, S.K.mar

Journal of Applied Animal Research 11(1): 49-56


ISSN/ISBN: 0971-2119
DOI: 10.1080/09712119.1997.9706160
Accession: 002813709

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Adult Stephanurus dentatus obtained from the kidney and nodulated fat found around the kidney of common Indian pig (Sus scrofa) were exposed to 10-4 and 10-5M hexachlorophene at 37 degree C. The mortality of the parasites was observed after an exposure of 30 minutes in 10-4M and an hour in 10-5M hexachlorophene. The effect of compound was also studied on various enzyme systems in the homogenates of the treated worms. Hexachlorophene in the concentration of 10-4M inhibited oxaloacetate reduction by 51% and 78%, and malate oxidation by 24% and 29% whereas, 10-5 M concentration caused an inhibition of 41% and 54% oxaloacetate reduction and 11% and 17% malate oxidation in male and female S. dentatus, respectively. And phosphomnoesterase activity was inhibited by 28% in male and 37% in female parasites with 10-4M hexachlorophene. The same concentration reduced the alkaline phosphomoesterase activity by 75% and 80% in males and females, respectively. 10-5M hexachlorophene also caused a significant reduction of these enzymes. However, cholinesterase activity did not show any change upon hexachlorophene administration.