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Effect of monoclonal antibodies on the entry and development of Plasmodium vivax sporozoites in cultured cells

, : Effect of monoclonal antibodies on the entry and development of Plasmodium vivax sporozoites in cultured cells. Chinese Journal of Parasitology and Parasitic Diseases 13(4): 284-289

The effects of MAbs against sporozoites (2F2, NVS3, 2E10) and blood stages (4B2, 8E3) of Plasmodium vivax on the entry and subsequent development of sporozoites in HepG2-A16 cells were investigated. The inhibitory effects against attachment and entry were related to antibody concentration. At 25 micro g/ml, inhibition of invasion was 100% for 2F2, 76% for NVS3 and 10.5% for 2E10.

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