+ Translate

Effect of pharmacological agonists on contractile responses in aortic rings derived from endotoxaemic rats

, : Effect of pharmacological agonists on contractile responses in aortic rings derived from endotoxaemic rats. Journal of Veterinary Pharmacology & Therapeutics 19(5): 389-396

To investigate the vascular smooth muscle dysfunction of septic shock, in vitro isometric responses to phenylephrine (PE) and acetylcholine (ACh) were evaluated in aortic rings, with and without endothelium (+-E), removed from male Wistar rats 1.5, 3 and 6 h after intravenous (i.v.) administration of 5 mg/ kg lipopolysaccharide (LPS) or vehicle. A reduction in maximum contraction (+-E) and sensitivity (-E) to PE were identified at 6 but not at 1.5 or 3 h. Maximum relaxation to ACh (+E) was not affected by LPS treatment but sensitivity was increased at 1.5 and 3 h. Having identified 6 h as the time at which the most pronounced changes were observed, further studies at this interval found that maximum contraction to potassium chloride (+-E), prostaglandin F-2alpha (+E) and detomidine (-E) and relaxation to salbutamol (- E) were less in aortic rings from endotoxaemic rats. Sensitivity to KCl (+-E), PGF-2alpha (-E) and detomidine (-E) was also reduced. Relaxation to sodium nitroprusside and atrial natriuretic peptide was not changed. These results suggest that attenuated pressor responses to a variety of vasoactive agents may be expected in patients 6 h after systemic exposure to endotoxin and that this vasoplegia may influence the vascular side-effects of therapeutic agents.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 002815839

PMID: 8905574

DOI: 10.1111/j.1365-2885.1996.tb00069.x

Download PDF Full Text: Effect of pharmacological agonists on contractile responses in aortic rings derived from endotoxaemic rats

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Portnoĭ, L.M.; Denisov, V.A.; Vasil'ev, I.D.; Koval'kov, A.I.; Roslov, A.L., 1985: Retrograde pancreatocholangiography in the diagnosis of organic diseases of the hepatopancreatoduodenal area. Khirurgiia: 74-79

Yamamoto T.; Fujii M.; Inuki T.; Iwasaki M.; Kojima H.; Miyoshi A.; Wakisaka G., 1968: The studies on shunt bilirubin iii abstract human hemolytic anemia. Gastroenterologia Japonica 3(2): 116-117

Andrews, W.H.; Deane, B.M.; Howe, A.; Orbach, J., 1972: Abdominal chemoreceptors in the rat. Journal of Physiology 222(1): 84p-85p

Talbot, S.; Kilpatrick, D.; Weeks, B., 1980: QRS waveform of ventricular extrasystoles and their differentiation from aberrant conduction. Horizontal and frontal plane QRS loops of patients in sinus rhythm with uniform ventricular extrasystoles were constructed from digitised Frank orthogonal electrocardiogram. In 4 patients ventricular extrasystoles were indistinguishable from right...

Sumina O.I., 1975: Vegetation of baydjarachs of kotelny island new siberian islands russian sfsr ussr. Botanicheskii Zhurnal (St Petersburg) 60(9): 1311-1319

Ristovski, V.; Scekic, V.; Radovanovic, N., 1999: Importance of Digoxin determination in serum of patients after open heart surgery. Clinical Chemistry & Laboratory Medicine 37(SPEC SUPPL ): S316, June

Cho, C.T.; Feng, K.K., 1977: Synergistic effects of antiviral agents and humoral antibodies in experimental Herpesvirus hominis encephalitis. Experimental Herpesvirus hominis encephalitis in 3-week-old Swiss mice was utilized to evaluate the antiviral effects of adenine arabinoside (ara-A), phosphonacetic acid (PAA), and humoral antibodies to H. hominis (HIG). Administration of ara-A, P...

Lupton, J.R., 2004: Microbial degradation products influence colon cancer risk: the butyrate controversy. All dietary fiber, by definition, escapes digestion in the small intestine and thus arrives relatively intact in the large intestine. Its fate in the large intestine depends upon the type of fiber and the colonic microflora. Highly fermentable fib...

Gagnieu C.H.; Grouiller A.V., 1982: A new procedure for olefin oxiranation by per oxy benzimidic acid synthesis of some carbohydrate precursor oxiranes and other epoxides. Synthesis of cis- and trans-2-methoxy-3,4-epoxytetrahydropyrans, 3,4-anhydro-1,2-isopropylidene-.beta.-D-L-arabinopyranose, and the cis- and trans-2-methoxy-3,4-epoxytetrahydrofurans, which are carbohydrate-precursor oxirans, using a new procedure...

Wenlock, Rw, 1979: Food intakes and nutritional status - implications for the formulation of development policies for Zambia. The results of surveys of food consumption and nutritional status of the rural Zambian population are combined, and the risk of nutritionally and anthropometrically defined deficiencies is related to measured nutrient intakes. The main nutrition...