EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Estimation of glomerular filtration rate in normal sheep by the disappearance of iohexol from serum






Veterinary Research Communications 21(1): 29-35

Estimation of glomerular filtration rate in normal sheep by the disappearance of iohexol from serum

The aim of the study was to establish reference values for glomerular filtration rate (GFR) in healthy sheep from the clearance of iohexol in serum. Fifteen healthy sheep were tested twice with 14 to 21 days between tests. No side-effects were observed after iohexol injections and all the sheep were clinically normal during and after the study. The mean clearance of iohexol estimated by the two-compartment method was 1.8 ml/min per kg (95% CI = 1.6-2.0) in the first trial and 1.7 ml/min per kg (1.5-1.9) in the second trial. The mean GFR-iohexol estimated by a one-compartment method was 1.9 ml/min per kg (1.7-2.2) in the first trial and 1.8 ml/min per kg (1.6-2.0) in the second. The GFR values were similar to those reported for the inulin method. The results indicate that the iohexol method is valid for estimating GFR in sheep, and it is easier to perform than the inulin method.

Accession: 002831749

PMID: 9060140

DOI: 10.1023/b:verc.0000009698.28252.d1

Download PDF Full Text: Estimation of glomerular filtration rate in normal sheep by the disappearance of iohexol from serum



Related references

Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 1: How to measure glomerular filtration rate with iohexol?. Clinical Kidney Journal 9(5): 682-699, 2016

Iohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol?. Clinical Kidney Journal 9(5): 700-704, 2016

Estimation of glomerular filtration rate using plasma clearance of iohexol Establishing normal values in dogs. Journal of Veterinary Internal Medicine 15(3): 302, May-June, 2001

Estimation of glomerular filtration rate via 2- and 4-sample plasma clearance of iohexol and creatinine in clinically normal cats. American Journal of Veterinary Research 70(2): 176-185, 2009

Factors affecting glomerular filtration rate, as measured by iohexol disappearance, in men with or at risk for HIV infection. Plos One 9(2): E86311-E86311, 2015

A single plasma sample method for estimation of the glomerular filtration rate in infants and children using iohexol i. establishment of a body weight related formula for the distribution volume of iohexol. Scandinavian Journal of Clinical and Laboratory Investigation 51(4): 335-342, 1991

A comparison of the plasma disappearance of iohexol and 99mTc-DTPA for the measurement of glomerular filtration rate (GFR) in diabetes. Australian and New Zealand Journal of Medicine 29(5): 693-700, 2000

A comparison of the plasma disappearance of iohexol and 99mTc-DTPA for the measurement of glomerular filtration rate (GFR) in diabetes. Australian and New Zealand Journal of Medicine 29(5): 693-700, 1999

Estimation of glomerular filtration rate in dogs with 99M-Tc-DTPa and iohexol. Research In Veterinary Science. 58(2): 138-143, 1995

Glomerular filtration rate estimated by x ray fluorescence technique in children comparison between the plasma disappearance of technetium 99m dtpa and iohexol after urography. Scandinavian Journal of Clinical & Laboratory Investigation 50(2): 161-168, 1990