+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Evaluation of dexfenfluramine in a weight loss program for obese infertile women



Evaluation of dexfenfluramine in a weight loss program for obese infertile women



International Journal of Eating Disorders 19(2): 209-212



To evaluate the usefulness of dexfenfluramine as an adjunct to a group treatment program for obese infertile women. Twenty-one obese infertile women were referred by the Reproductive Medicine Unit. They attended a 24-week group program which included exercise and educational sessions. Dexfenfluramine and placebo were given, each for 12 weeks, in a double-blind crossover design. Dexfenfluramine treatment was not associated with greater loss of weight. The mean weight loss during dexfenfluramine treatment was 3.21 kg (SD 3.09) and during placebo was 3.31 kg (SD 3.15). Self-esteem, anxiety, and depression ratings all improved significantly over the 24 weeks. The group treatment program appeared to be equally effective with or without dexfenfluramine. Previous studies have found dexfenfluramine to be effective in combination with individual treatment, but it has not previously been evaluated as an adjunct to group treatment. It is unclear whether dexfenfluramine may be less effective in combination with group treatment programs, or whether its usefulness is restricted in this particular population of obese patients. No differences were found associated with the order in which active and placebo treatments were given. Patients showed improvement in self-esteem and reduction in depression and anxiety, but dexfenfluramine treatment was not associated with any difference in these measures, compared to placebo.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 002833647

Download citation: RISBibTeXText

PMID: 8932560

DOI: 10.1002/(sici)1098-108x(199603)19:2<209::aid-eat12>3.0.co;2-p


Related references

A group program for obese, infertile women: weight loss and improved psychological health. Journal of Psychosomatic Obstetrics and Gynaecology 17(2): 125-128, 1996

The effect of weight loss program on serum anti-Müllerian hormone level in obese and overweight infertile women with polycystic ovary syndrome. Gynecological Endocrinology 2018: 1-5, 2018

Effect of a Free Prepared Meal and Incentivized Weight Loss Program on Weight Loss and Weight Loss Maintenance in Obese and Overweight Women: A Randomized Controlled Trial. Yearbook of Obstetrics Gynecology and Women's Health 2011: 11-12, 2011

Effect of a free prepared meal and incentivized weight loss program on weight loss and weight loss maintenance in obese and overweight women: a randomized controlled trial. JAMA 304(16): 1803-1810, 2010

Metabolic indices in relation to body composition changes during weight loss on Dexfenfluramine in obese women from two South African ethnic groups. International Journal of Obesity and Related Metabolic Disorders 20(8): 768-776, 1996

Effects of weight loss on the hormonal profile in obese, infertile women. Human Reproduction 11(9): 1884-1891, 1996

Infertility: Effects of weight loss on the hormonal profile in obese, infertile women. Human Reproduction 11(9): 1884-1891, 1996

Effects of a popular exercise and weight loss program on weight loss, body composition, energy expenditure and health in obese women. Nutrition and Metabolism 6: 23, 2009

Association between periconceptional weight loss and maternal and neonatal outcomes in obese infertile women. Plos One 13(3): E0192670, 2018

Beneficial effect of high energy intake at lunch rather than dinner on weight loss in healthy obese women in a weight-loss program: a randomized clinical trial. American Journal of Clinical Nutrition 104(4): 982-989, 2016

Effect of weekly physical activity frequency on weight loss in healthy overweight and obese women attending a weight loss program: a randomized controlled trial. American Journal of Clinical Nutrition 104(5): 1202-1208, 2016

Evaluation of a commercial web-based weight loss and weight loss maintenance program in overweight and obese adults: a randomized controlled trial. Bmc Public Health 10: 669, 2011

Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Human Reproduction 13(6): 1502-1505, 1998

Prolonged weight loss with dexfenfluramine treatment in obese patients. Diabete and Metabolisme 13(6): 598-602, 1987

Sibutramine hydrochloride VS dexfenfluramine Weight loss in obese subjects. International Journal of Obesity 18(SUPPL 2): 61, 1994