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Evaluation of himachalol in murine invasive aspergillosis



Evaluation of himachalol in murine invasive aspergillosis



Mycoses 39(11-12): 449-452



Himachalol (a sesquiterpene alcohol) showed low in vitro minimum inhibitory concentrations against Aspergillus fumigatus by the macro- and microbroth dilution techniques (geometric mean 250 mu-g ml-1 and 46.4 mu-g ml-1 respectively) compared with saperconazole. Swiss mice treated with the phytoproduct (200 mg kg-1, p.o.) once daily for 7 days exhibited a significant (P lt 0.001) protection (60%) together with an increase in the mean survival time (15 days) and a reduced CFU (mean log-10) burden of A. fumigatus in the kidneys.

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Accession: 002833969

Download citation: RISBibTeXText

PMID: 9145002

DOI: 10.1111/j.1439-0507.1996.tb00095.x


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