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Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human alpha S1 casein (alpha S1-casomorphin, and alpha S1-casomorphin amide)

, : Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human alpha S1 casein (alpha S1-casomorphin, and alpha S1-casomorphin amide). Biochemical Journal 319: 903-908

A new casomorphin pentapeptide ( alpha s1-casomorphin) was isolated from the sequence of human alpha s1-casein ( alpha s1-casein-(158-162)), with the sequence Tyr-Val-Pro-Phe-Pro. This peptide bound with high affinity to all 3 subtypes of the kappa -opioid receptor ( kappa 1- kappa 3). When amidated at the C-terminus, alpha s1-casomorphin amide bound to the delta - and kappa 3-opioid sites.

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Accession: 002863212

PMID: 8920997

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