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Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human alpha S1 casein (alpha S1-casomorphin, and alpha S1-casomorphin amide)






Biochemical Journal 319: 903-908

Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human alpha S1 casein (alpha S1-casomorphin, and alpha S1-casomorphin amide)

A new casomorphin pentapeptide ( alpha s1-casomorphin) was isolated from the sequence of human alpha s1-casein ( alpha s1-casein-(158-162)), with the sequence Tyr-Val-Pro-Phe-Pro. This peptide bound with high affinity to all 3 subtypes of the kappa -opioid receptor ( kappa 1- kappa 3). When amidated at the C-terminus, alpha s1-casomorphin amide bound to the delta - and kappa 3-opioid sites.


Accession: 002863212

PMID: 8920997



Related references

Kampa, M.; Loukas, S.; Hatzoglou, A.; Martin, P.; Martin, P.M.rie; Castanas, E., 1996: Identification of a novel opioid peptide derived from human alpha-S1 casein. A new casomorphin pentapeptide (alpha-S1-casomorphin) has been isolated from the sequence of human alpha-S1-casein (alpha-S1-casein(158-162)), with the sequence Tyr-Val-Pro-Phe-Pro. This peptide was found to bind with high affinity to all three su...

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