+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790

, : Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. Journal of Dairy Science 79(8): 1316-1321

Casein hydrolysate, produced by an extracellular proteinase from Lactobacillus helveticus CP790, was fractionated by two-step reverse-phase HPLC. Only one fraction showed antihypertensive activity as measured by systolic blood pressure in spontaneously hypertensive rats after oral administration. Ten peptides in the fraction were further purified and identified by analysis of amino acid sequences. Each identified peptide was chemically synthesized, and the antihypertensive activity of each peptide was evaluated in spontaneously hypertensive rats. The synthetic peptide with a sequence of Lys-Val-Leu-Pro-Val-Pro-Gln, found in beta-casein, indicated strong antihypertensive activity from 2 to 10 h after oral administration of 2 mg of peptide/kg of BW, and the effect was maximal at 6 h after oral administration (-31.5 +/- 5.6 mm Hg). Moreover, the antihypertensive effect of the peptide was dependent on the dosage of peptide from 0.5 to 2 mg of peptide/kg of BW. Interestingly, the antihypertensive peptide showed lower inhibitory activity of angiotensin I-converting enzyme, but the activity was increased after pancreatin digestion.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 002863299

PMID: 8880454

DOI: 10.3168/jds.S0022-0302(96)76487-1

PDF Full Text: Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Huisman, T.H.J.; Schillhorn Van Veen, J.M., 1964: Studies on animal hemoglobins. III. The possible role of intercellular inorganic phosphate on the oxygen equilibrium of the hemoglobin in the developing chicken. The hemo-globin of red cell hemolysates of chicken embryos and chickens after hatching have been reinvestigated using starch-gel electrophoresis and O2 equilibrium measurements. Three hemoglobin components were found, namely the major and minor he...

Chokkalingam S.; Viswanathan B.; Varadarajan T.K., 1985: Catalytic properties of beta cobalt molybdate in the decomposition of isopropyl alcohol. .beta.-CoMoO4 (violet modification) promotes dehydrogenation of isopropyl alcohol in absence of gaseous oxygen while in presence of gaseous oxygen only oxidative dehydrogenation occurs. Dehydration of isopropyl alcohol is also promoted by the cata...

Anonymous, 2012: Sulfur isotope variability of oceanic DMS-DMSP. Oceanic dimethylsulfoniopropionate (DMSP) is the precursor to dimethylsulfide (DMS), which plays a role in climate regulation through transformation to methanesulfonic acid (MSA) and non-seasalt sulfate (NSS-SO42?) aerosols. Here, we report measur...

Kraus, P.; Horácek, J., 1970: Problems of the so-called benign lymphoepithelial lesion of the salivary glands (Godwin). Monatsschrift für Ohrenheilkunde und Laryngo-Rhinologie 104(6): 251-256

Khanin, M.A.; Bukharov, I.B.; Kossov, A.S., 1971: Regulation mechanism of pulmonary diffusing capacity. Doklady Akademii Nauk SSSR 201(3): 728-730

Cox, C.; Wilson, R., 1979: Arlington, Virginia revamps food program, raises sanitation level. Journal of environmental health 41(4): 208-211

DAYANANDARAO, B., 1952: Total excision of os-calcis for chronic osteomyelitis; a case report. Indian Journal of Surgery 14(2): 188-189

Cao, Y.; Su, J.; Zhang, T.; Lian, X., 2006: Investigation on helminth eggs in feces of Tibetan antelope, wild yak, Tibetan wild ass and Tibetan gazelle. Sichuan Journal of Zoology. August 28; 253: 611-614

Itoi M., 1989: Keratoconus experience of 2680 cases. This paper summarizes 15 years of clinical experience at our keratoconus clinic. Of 2680 new keratoconus patients, 2518 had typical keratoconus, 99 had atypical 57 had secondary and 6 had borderline keratoconus. We had eleven keratoconus pedigrees...

Qiu, L.Yan.; Koenderink, J.B.; Swarts, H.G.P.; Willems, P.H.G.M.; D.P.nt, J.Joep.H.H.M., 2003: Phe783, Thr797, and Asp804 in transmembrane hairpin M5-M6 of Na+,K+-ATPase play a key role in ouabain binding. Ouabain is a glycoside that binds to and inhibits the action of Na+,K+-ATPase. Little is known, however, about the specific requirements of the protein surface for glycoside binding. Using chimeras of gastric H+,K+-ATPase and Na+,K+-ATPase, we dem...