+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Identification of larval-stage-specific antigens of Onchocerca volvulus uniquely recognized by putative immune sera from humans and vaccination sera from animal models

, : Identification of larval-stage-specific antigens of Onchocerca volvulus uniquely recognized by putative immune sera from humans and vaccination sera from animal models. Annals of Tropical Medicine and Parasitology 91(1): 67-77

Immunity to Onchocerca volvulus is indicated by the existence of putative immune individuals (PI), who do not develop patent infections or clinical symptoms after living in endemic areas for extended periods of time. To gain insight into the nature of the humoral response of PI from Liberia and Ecuador, their sera and those of infected individuals were investigated and compared using western blots. The antigen preparations used were extracts of third- and fourth-stage larvae (L3 and L4, respectively), excretory-secretory proteins (ES-L3) and extracts of third-stage larvae (L3-day2) that had been cultured for 2 days, and extracts of nodular and skin microfilariae. Whereas some antigens were commonly recognized by all individuals, many stage-specific antigens (of 68, 60, 55, 46, 43, 42, 20 and 18 kDa in L3; 100, 88, 80, 50, 48, 45, 40 and 20 kDa in L3-day2; 110, 80 and 72 kDa in ES-L3; 48, 18, 16 and 14 kDa in L4; and 115, 60, 47, 43 and 17 kDa in skin and/or nodular microfilariae) were uniquely recognized by sera from PI. Some of the unique antigens were also recognized by sera from mice and a chimpanzee that were resistant to challenge after immunization with irradiated third-stage larvae. The results support the validity of the assumption that a unique status of immunity develops in certain individuals living in areas where onchocerciasis is endemic.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 002863553

PMID: 9093431

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Custer, Lind; Mullon, Claudy; Butterworth, Roger, 2000: Astrocyte apparatus for bioprocessing a circulating fluid. The invention relates to a container having astrocytes for use in removing toxins from a biological fluid. The container includes a first port for receiving the biological fluid and a second port through which the biological fluid exits the contai...

Swarup R.; Swarup G., 1988: Effects of cyst extraction techniques on biology of heterodera avenae. Cysts of Heterodera avenae extracted through zinc sulphate, magnesium sulphate, acetone and ethanol + glycerine have been compared with manually extracted ones with regard to efficiency of the method and their effect on larval penetration and deve...

Tamayo, C.-R; Castro, D.-Cr; Schoebitz, T.-Dr, 1984: Feeds contaminated with aflatoxins. Agro sur 12(1): 65-66

Kruglik, S.G.; Lambry, J-Christophe.; Cianetti, S.; Martin, J-Louis.; Eady, R.R.; Andrew, C.R.; Negrerie, M., 2006: Molecular basis for nitric oxide dynamics and affinity with Alcaligenes xylosoxidans cytochrome c. The bacterial heme protein cytochrome c' from Alcaligenes xylosoxidans (AXCP) reacts with nitric oxide (NO) to form a 5-coordinate ferrous nitrosyl heme complex. The crystal structure of ferrous nitrosyl AXCP has previously revealed that NO...

Jucker W.; Ettlinger L., 1985: The inhibition of acetate oxidation by ethanol in acetobacter aceti. Ethanol grown Acetobacter aceti differed from acetate grown. In ethanol grown cells, acetate uptake, caused by the oxidation of acetate, was completely inhibited by ethanol, in acetate grown cells only to 20%. This was correlated with a 65-fold hi...

Park, S.; Gwak, J.; Cho, M.; Song, T.; Won, J.; Kim, D-Eun.; Shin, J-Gook.; Oh, S., 2006: Hexachlorophene inhibits Wnt/beta-catenin pathway by promoting Siah-mediated beta-catenin degradation. Aberrant activation of Wnt/beta-catenin signaling and subsequent up-regulation of beta-catenin response transcription (CRT) is a critical event in the development of human colon cancer. Thus, Wnt/beta-catenin signaling is an attractive target for...

Krepinsky, J.J., 1988: Formation and biological effects of fecapentaenes. Progress in Biochemical Pharmacology 22(): 35-47

MOSES, C.; KENT, E.; BOATMAN, J.B., 1955: Experimental and clinical studies with radioactive colloidal gold in the therapy of serous effusions arising from cancer. The distribution and toxicity of colloidal radiogold (Au198) following its intrapleural and intraperitoneal instillation in rats were studied. No significant complications were encountered with doses comparable to those used clinically. The Au198,...

Aulisio, C.C.; Hill, W.E.; Stanfield, J.T.; Sellers, R.L., 1983: Evaluation of virulence factor testing and characteristics of pathogenicity in Yersinia enterocolitica. The virulence of 10 strains of Yersinia enterocolitica containing 42- to 44-megadalton plasmids (serogroups O:3; O:4,32; O:8; O:9; O:13,7; and O:21) was compared in mice and guinea pigs. Adult mice were more responsive than guinea pigs to the Sere...

Drzewiecki, Peter; Wizevich, Michael C., 2008: Sequence stratigraphy and depositional controls of continental strata; example from the Jurassic East Berlin Formation, Hartford Basin, Connecticut. Depositional sequences of continental strata often respond more to tectonic- and climate-controlled changes in sediment and water supply than to changes in accommodation associated with base level rise or fall. This can lead to significantly diffe...