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Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4

, : Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4. Virology 231(2): 231-238

Downregulation of call surface CD4 is a characteristic property of all lentiviral Nef proteins. We have used mutational analysis to define regions within HIV-1 Nef that are critical for this biological activity. Two discontinuous regions In Nef, extending approximately from residues 96 to 144 and from residues 175 to 186, are reported to be essential for efficient CD4 downregulation. Interestingly, these sequences coincide with two conserved regions of the Nef protein that are juxtaposed to form a single surface on the known structure of Nef. A third, more amino terminal conserved region in Nef, previously reported to be important for Nef enhancement of virion infectivity, was found to be largely dispensable for CD4 downregulation. These data raise the possibility that Nef may contain two structurally distinct functional domains, only one of which contributes to the CD4 downregulation phenotype.

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Accession: 002863738

PMID: 9168885

DOI: 10.1006/viro.1997.8517

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Other references

CEDERMARK, J., 1949: Neurinoma in the gastro-intestinal tract. Acta Chirurgica Scandinavica 97(6): 473-484

Hollen, P.J., 1994: Psychometric properties of two instruments to measure quality decision making. The results of testing two instruments for consequential decision making are reported: a screening instrument, the Decision Making Quality Scale (DMQS), which assesses the degree to which a person adheres to seven quality criteria of decision maki...

Song, H.-Wei; Chang, W.-Rui; Liang, D.-Cai, 1993: Studies on the crystal structure of (L-Met)-B0 bovine insulin at 3.0 A resolution. Based on the crystal symmetry of (L-Met)-B0 bovine insulin (LMBBI) and the fundamental theory of the molecular packing method, the scheme for the determination of the position and orientation of the molecules by only using one-dimensional rotation...

Cao, X.; Lu, Y.; Di, D.; Zhang, Z.; Liu, H.; Tian, L.; Zhang, A.; Zhang, Y.; Shi, L.; Guo, B.; Xu, J.; Duan, X.; Wang, X.; Han, C.; Miao, H.; Yu, J.; Li, D., 2013: Enhanced virus resistance in transgenic maize expressing a dsRNA-specific endoribonuclease gene from E. coli. Maize rough dwarf disease (MRDD), caused by several Fijiviruses in the family Reoviridae, is a global disease that is responsible for substantial yield losses in maize. Although some maize germplasm have low levels of polygenic resistance to MRDD,...

Cohain, J.Slome.; Yoselis, A., 2004: Caesareans and low-risk women in Israel. Randomised retrospective study of the rise in caesarean surgery among low-risk women between 1990 and 2000 at Hadassah Ein Kerem Labor and Delivery Unit in Jerusalem. The CS rate in low-risk women increased from 4 per cent to 10.5 per cent. Approx...

Mehta, J.M., 1980: Medical certification of leprosy patients and reservation in service for the physically handicapped, including persons with leprosy. International Journal of Leprosy and Other Mycobacterial Diseases 48(3): 332-333

Haslett Simon K., 1990: Magnetic survey of a monchiquite intrusion in central Gwent. Geological Magazine 127(6): 591-592

D'Este, L.; Falconieri-Erspamer, G.; Severini, C.; Erspamer, V.; Renda, T.G., 1999: Neuropeptide Y release by pumiliotoxin-B in the electrically-stimulated mouse vas deferens: an immunohistochemical study. Morphologic and immunohistochemical studies were conducted to ascertain whether pumiliotoxin-B (PTX-B), an indolizine alkaloid from the skin of the Neotropical dendrobatid frog, Dendrobates pumilio, affects the anatomic and immunohistochemical fea...

Vestling C.S., 1969: Rat liver lactate dehydrogenase an inclusive study. Schwert, George W And Alfred D Winer (Edited By) The Mechanism Of Action Of Dehydrogenases A Symposium in Honor Of Hugo Theorell Xi + 256p Illus The University Press Of Kentucky: Lexington, Ky , U S A 43-62

Auber, J., 1955: Au sujet du Nemoptere de France Planip. Bulletin de la Societe Entomologique de France Paris, 60: 170-173