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In vitro and in vivo antiviral (RNA) evaluation of orotidine 5'-monophosphate decarboxylase inhibitors and analogues including 6-azauridine-5'-(ethyl methoxyalaninyl) phosphate (a 5'-monophosphate prodrug)



In vitro and in vivo antiviral (RNA) evaluation of orotidine 5'-monophosphate decarboxylase inhibitors and analogues including 6-azauridine-5'-(ethyl methoxyalaninyl) phosphate (a 5'-monophosphate prodrug)



Antiviral Chemistry and Chemotherapy 5(4): 209-220



The RNA viruses used in this study were: Japanese encephalitis (JE), yellow fever, sandfly fever, Punta Toro (PT) and Venezuelan equine encephalomyelitis (VEE) viruses. 2-Thio-6-azauridine showed the best in vitro activity against all 5 viruses. In vivo activity was not, however, observed in JE-, PT- and VEE-infected mice. The phosphate prodrug of 6-azauridine was significantly more effective than the parent compound in the PT virus mouse model.

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Accession: 002867260

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DOI: 10.1177/095632029400500402


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