Intracellular survival of protozoan parasites with special reference to Leishmania spp., Toxoplasma gondii and Trypanosoma cruzi
Mauël, J.
Advances in Parasitology 38: 1-51
1996
ISSN/ISBN: 0065-308X
PMID: 8701794
Accession: 002877869
The survival and proliferation of parasitic protozoa within host cells are reviewed under the following headings: entering the host cell (conventional phagocytosis: the Leishmania case; active invasion), avoiding intracellular killing mechanisms (phagolysosome formation and the microbicidal activities of host cells; resistance to lysosomal toxicity; interference with the respiratory burst of phagocytes; inhibition of nitric oxide synthesis; other inhibitory effects), and meeting nutritional requirements (different strategies for different parasites; metabolic adaptation to intracellular life; acquisition of nutrients). There is particular reference to Leishmania, Toxoplasma gondii and Trypanosoma cruzi throughout.