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Chapter 2,878

Intracellular survival of protozoan parasites with special reference to Leishmania spp., Toxoplasma gondii and Trypanosoma cruzi

Mauël, J.

Advances in Parasitology 38: 1-51

1996


ISSN/ISBN: 0065-308X
PMID: 8701794
Accession: 002877869

The survival and proliferation of parasitic protozoa within host cells are reviewed under the following headings: entering the host cell (conventional phagocytosis: the Leishmania case; active invasion), avoiding intracellular killing mechanisms (phagolysosome formation and the microbicidal activities of host cells; resistance to lysosomal toxicity; interference with the respiratory burst of phagocytes; inhibition of nitric oxide synthesis; other inhibitory effects), and meeting nutritional requirements (different strategies for different parasites; metabolic adaptation to intracellular life; acquisition of nutrients). There is particular reference to Leishmania, Toxoplasma gondii and Trypanosoma cruzi throughout.

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