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Lymphocyte proliferation and blood drug levels in dogs with keratoconjunctivitis sicca receiving long-term topical ocular cyclosporine



Lymphocyte proliferation and blood drug levels in dogs with keratoconjunctivitis sicca receiving long-term topical ocular cyclosporine



Veterinary & Comparative Ophthalmology 6(2): 125-130



To determine the long-term systemic effect of the use of topical ocular cyclosporine (CsA), peripheral lymphocyte proliferation and blood CsA levels were measured in 10 dogs with keratoconjunctivitis sicca (KCS) that were being treated with topical ocular 2% CsA for a duration of at least 3 months. Twelve dogs of similar ages and gender to the dogs with KCS that were not receiving medication were used for comparison in the lymphocyte proliferation and cyclosporine assays. The lymphocyte stimulation index (SI) of the lymphocyte proliferation assay was significantly less in the CsA treated dogs (4.7 +- 3.7) than the non-KCS dogs (18.0 +- 12.3; P = 0.004). Six of 10 CsA-treated dogs had detectable levels of peripheral blood CsA and the overall mean blood level in CsA-treated dogs was 22.0 +- 7.4 ng/ml. None of the normal dogs had measurable levels of blood CsA. These preliminary results suggest that topical ocular 2% cyclosporine is absorbed systemically and causes suppression of cellular immunity. The adverse effects of this immunosuppression, if any, and the effects of the peripheral immunosuppression on the lacrimal gland pathology has yet to be determined.

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Accession: 002888388

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