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Major histocompatibility and T-cell receptor genes in artiodactyls: characterization, polymorphism and genetic resistance to a helmintic infection


, : Major histocompatibility and T-cell receptor genes in artiodactyls: characterization, polymorphism and genetic resistance to a helmintic infection. Journal of Animal Breeding and Genetics 113(4-5): 287-291

Resistance or susceptibility to an infectious disease is determined to some extend by.genetic variation of the host. This genetic variation can be used to breed more resistant animals to reduce costs for the control of the infection. Since the recording of parameters for disease resistance is usually time consuming, it was not feasible to include these into classical selection indices. Disease resistance associated markers could be used to select for this trait more efficiently. We developed PCR based characterization of an artiodactyl T cell receptor variable element (TCRVB6) and a major histocompatibility complex (MHC)-DRB gene. Both genes could be amplified in a wide range of artiodactyl species. They harbour simple repetitive sequences in almost the same genomic position as in the human homologes. We developed an MHC-DRB typing system combining the microsatellite information with the hybridization of polymorphism specific oligonucleotides. To investigate possible associations to the faecal egg count (FEC), a flock of Scottish Blackface sheep has been typed for the TCRBV and the MHC-DRB loci. The MHC-DRB showed a highly significant association to the FEC. Potential applications and evolutionary aspects are discussed.

Accession: 002889182

DOI: 10.1111/j.1439-0388.1996.tb00618.x

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