EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Major histocompatibility and T-cell receptor genes in artiodactyls: characterization, polymorphism and genetic resistance to a helmintic infection


Journal of Animal Breeding and Genetics 113(4-5): 287-291
Major histocompatibility and T-cell receptor genes in artiodactyls: characterization, polymorphism and genetic resistance to a helmintic infection
Resistance or susceptibility to an infectious disease is determined to some extend by.genetic variation of the host. This genetic variation can be used to breed more resistant animals to reduce costs for the control of the infection. Since the recording of parameters for disease resistance is usually time consuming, it was not feasible to include these into classical selection indices. Disease resistance associated markers could be used to select for this trait more efficiently. We developed PCR based characterization of an artiodactyl T cell receptor variable element (TCRVB6) and a major histocompatibility complex (MHC)-DRB gene. Both genes could be amplified in a wide range of artiodactyl species. They harbour simple repetitive sequences in almost the same genomic position as in the human homologes. We developed an MHC-DRB typing system combining the microsatellite information with the hybridization of polymorphism specific oligonucleotides. To investigate possible associations to the faecal egg count (FEC), a flock of Scottish Blackface sheep has been typed for the TCRBV and the MHC-DRB loci. The MHC-DRB showed a highly significant association to the FEC. Potential applications and evolutionary aspects are discussed.

Accession: 002889182

DOI: 10.1111/j.1439-0388.1996.tb00618.x

Download PDF Full Text: Major histocompatibility and T-cell receptor genes in artiodactyls: characterization, polymorphism and genetic resistance to a helmintic infection



Related references

Major histocompatibility and T-cell receptor genes in artiodactyls: Characterization, polymorphism and genetic resistance to a helminthic infection. Journal of Animal Breeding & Genetics 113(4-5): 287-291, 1996

Nature of the T-cell receptor. Both the T-cell receptor and antigen-specific T-cell-derived factors are coded for by V genes but express anti-self idiotypes indirectly determined by major histocompatibility complex genes. Scandinavian Journal of Immunology 10(5): 387-393, 1979

Genetic polymorphism of the swine major histocompatibility complex ( SLA) class I genes, SLA-1, -2 and -3. Immunogenetics 55(9): 583-593, 2003

Genetic polymorphism of a bovine t-complex gene (TCP1) linkage to major histocompatibility genes. Journal of Heredity 79(1): 1-5, 1988

Genetic polymorphism and expression in various tissues of the miniature swine major histocompatibility complex class I genes, SLA-1, -2, -3, -6, -7 and -8. Xenotransplantation 8(Supplement 1): 82, August, 2001

Human major histocompatibility complex class iii genes properdin factor b and complement c 4 polymorphism complotypes and association with major histocompatibility complex class i genes in the finnish population. Human Heredity 36(5): 269-275, 1986

Characterization, polymorphism and selection of major histocompatibility complex (MHC) DAB genes in vulnerable Chinese egret (Egretta eulophotes). Plos One 8(9): E74185-E74185, 2014

The T cell receptor repertoire of intestinal intraepithelial cd T lymphocytes is influenced by genes linked to the major histocompatibility complex and to the T cell receptor loci. Proceedings of the National Academy of Sciences of the United States of America 94: 61-6, 1997

The T cell receptor repertoire of intestinal intraepithelial gammadelta T lymphocytes is influenced by genes linked to the major histocompatibility complex and to the T cell receptor loci. Proceedings of the National Academy of Sciences of the United States of America 94(11): 5761-5766, 1997

Genetic polymorphism of major histocompatibility complex class IIB alleles and pathogen resistance in the giant spiny frog Quasipaa spinosa. Infection, Genetics and Evolution 28: 175-182, 2015