EurekaMag.com logo
+ Translate

Malaria cytoadherence: binding sites for an anti-adhesive antibody on Plasmodium falciparum-infected erythrocytes


, : Malaria cytoadherence: binding sites for an anti-adhesive antibody on Plasmodium falciparum-infected erythrocytes. Annals of Tropical Medicine and Parasitology 89(6): 685-686

The number of 1C4 molecules (a MAb which inhibits the binding of Plasmodium falciparum-infected erythrocytes to C32 amelanotic melanoma cells) that could potentially bind to the surface of infected erythrocytes was determined using an indirect method involving 125I-protein-A to detect the bound IgG. The mean number of 1C4 molecules which bound was calculated as 3089/infected erythrocyte.

(PDF 0-2 workdays service)

Accession: 002889316

PMID: 8745943

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

David, P.H.; Hommel, M.; Miller, L.H.; Udeinya, I.J.; Oligino, L.D., 1983: Parasite sequestration in Plasmodium falciparum malaria: spleen and antibody modulation of cytoadherence of infected erythrocytes. Sequestration, the adherence of infected erythrocytes containing late developmental stages of the parasite (trophozoites and schizonts) to the endothelium of capillaries and venules, is characteristic of Plasmodium falciparum infections. We have s...

Smith, H.; Nelson, J.A.; Gahmberg, C.G.; Crandall, I.; Sherman, I.W., 1992: Plasmodium falciparum: cytoadherence of malaria-infected erythrocytes to human brain capillary and umbilical vein endothelial cells--a comparative study of adhesive ligands. The cytoadherence of Plasmodium falciparum-infected erythrocytes (FCR-3 line) to human brain capillary endothelial cells (HBEC), C32 amelanotic melanoma cells, and human umbilical vein endothelial cells (HUVEC) was studied. The adhesion of infecte...

Yeung, J.; Brown, J.T.; Nair, A.; Meites, E.; Coppel, R.L.; Mohandas, N.; Meyer-Ilse, W.; Magowan, C., 1998: X-ray microscopic visualization of specific labeling of adhesive molecule CD36 and cytoadherence by Plasmodium falciparum infected erythrocytes. We investigated the cytoadherence of Plasmodium falciparum infected erythrocytes to target cells that express CD36 by soft x-ray microscopy. Using immunogold beads enhanced with silver, we localized CD36 on the surface of intact melanoma cells and...

Leech, J.H.; Aley, S.B.; Miller, L.H.; Howard, R.J., 1984: Plasmodium falciparum malaria: cytoadherence of infected erythrocytes to endothelial cells and associated changes in the erythrocyte membrane. Evidence that knobs mediate cytoadherence of P. falciparum-infected erythrocytes to endothelial cells is reviewed. An in vitro model of cytoadherence is described, followed by a review of recent studies which demonstrate the inhibition of cytoadhe...

Rogerson, S.J.; Tembenu, R.; Dobaño, C.; Plitt, S.; Taylor, T.E.; Molyneux, M.E., 1999: Cytoadherence characteristics of Plasmodium falciparum-infected erythrocytes from Malawian children with severe and uncomplicated malaria. Fresh Plasmodium falciparum isolates obtained between January and June 1997 from Malawian children with severe (n=76) or uncomplicated (n=79) malaria were cultured to the pigmented trophozoite stage and examined for rosette formation and adherence...

Almelli, T.; Ndam, N.T.; Ezimegnon, S.; Alao, M.J.; Ahouansou, C.; Sagbo, G.; Amoussou, A.; Deloron, P.; Tahar, R., 2015: Cytoadherence phenotype of Plasmodium falciparum-infected erythrocytes is associated with specific pfemp-1 expression in parasites from children with cerebral malaria. Cytoadherence of Plasmodium falciparum-infected erythrocytes (IEs) in deep microvasculature endothelia plays a major role in the pathogenesis of cerebral malaria (CM). This biological process is thought to be mediated by P. falciparum erythrocyte...

Xiao, L.; Yang, C.; Dorovini Zis, K.; Tandon, N.N.; Lal, A.A.; Udhayakumar, V., 1995: Cytoadherence of Plasmodium falciparum infected erythrocytes to endothelial cells may involve unidentified cytoadherence receptor. FASEB Journal 9(3): A231

Sherman I.W.; Winograd E., 1990: A modified band 3 protein expressed on the surface of erythrocytes infected with a knobby line of plasmodium falciparum human malaria is involved in cytoadherence. Cohen, C M And J Palek (Ed ) Ucla (University Of California-Los Angeles) Symposia on Molecular And Cellular Biology New Series, Vol 118 Cellular And Molecular Biology Of Normal And Abnormal Erythroid Membranes; Taos, New Mexico, Usa, February 3-10, 1989 Xviii+339p Wiley-Liss: New York, New York, Usa; Chichester, England, Uk Illus 283-300

Crandall, I.; Sherman, I.W., 1994: Antibodies to synthetic peptides based on band 3 motifs react specifically with Plasmodium falciparum (human malaria)-infected erythrocytes and block cytoadherence. Rabbit polyclonal and mouse monoclonal antibodies (MAbs) prepared against synthetic peptides patterned on exofacial loops 3 (amino acids 546-555) and 7 (821-834) of the human anion transport protein band 3 inhibited the cytoadherence of Plasmodium...

Muthusamy, A.; Achur, R.N.; Bhavanandan, V.P.; Gowda, D.C., 2003: Cytoadherence of Plasmodium falciparum infected erythrocytes in the placenta Evaluation of differentially sulfated chondroitin sulfate proteoglycans for binding. American Journal of Tropical Medicine & Hygiene 69(3 Supplement): 479-480, September