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Malaria cytoadherence: binding sites for an anti-adhesive antibody on Plasmodium falciparum-infected erythrocytes

, : Malaria cytoadherence: binding sites for an anti-adhesive antibody on Plasmodium falciparum-infected erythrocytes. Annals of Tropical Medicine and Parasitology 89(6): 685-686

The number of 1C4 molecules (a MAb which inhibits the binding of Plasmodium falciparum-infected erythrocytes to C32 amelanotic melanoma cells) that could potentially bind to the surface of infected erythrocytes was determined using an indirect method involving 125I-protein-A to detect the bound IgG. The mean number of 1C4 molecules which bound was calculated as 3089/infected erythrocyte.

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Accession: 002889316

PMID: 8745943

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David, P.H.; Hommel, M.; Miller, L.H.; Udeinya, I.J.; Oligino, L.D., 1983: Parasite sequestration in Plasmodium falciparum malaria: spleen and antibody modulation of cytoadherence of infected erythrocytes. Sequestration, the adherence of infected erythrocytes containing late developmental stages of the parasite (trophozoites and schizonts) to the endothelium of capillaries and venules, is characteristic of Plasmodium falciparum infections. We have s...

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