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Malaria vaccines: attacking infected erythrocytes


, : Malaria vaccines: attacking infected erythrocytes. Malaria vaccine development: a multi immune response approach: 105-143

This chapter discusses the different immune mechanisms that may give rise to protection against asexual blood-stage infections both in experimental systems and in humans with Plasmodium falciparum malaria under the headings: the asexual erythrocytic cycle; protective immune responses against asexual erythrocytic stages in rodent malaria models; regulation of immunity to P. falciparum (antibodies, cellular regulation, genetic regulation); possible mechanisms of parasite neutralization; possible target antigens for protective immune responses (antigens exposed on the surface of infected erythrocytes, antigens associated with the surface of the parasite, exoantigens); progress toward developing vaccines based on specific antigens (including PfMSP-1); vaccine-related problems (trials in monkeys; immunogenicity, adjuvants and delivery systems).

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