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Malaria, mefloquine and the mind


, : Malaria, mefloquine and the mind. New Zealand Medical Journal 110(1042): 137-138


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Accession: 002889391

PMID: 9152353

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Sowunmi, A.; Gbotosho, G.O.; Happi, C.; Okuboyejo, T.; Folarin, O.; Balogun, S.; Michael, O., 2010: Therapeutic efficacy and effects of artesunate-mefloquine and mefloquine alone on malaria-associated anemia in children with uncomplicated Plasmodium falciparum malaria in southwest Nigeria. The treatment efficacy and effects of artesunate-mefloquine (AMQ) and mefloquine (MQ) on malaria-associated anemia (MAA) were evaluated in 342 children <or= 10 years of age with uncomplicated Plasmodium falciparum malaria randomized to receive...

Harinasuta T.; Lasserre R.; Bunnag D.; Leimer R.; Vinijanont S., 1985: Trials of mefloquine in vivax malaria and of mefloquine plus fansidar in falciparum malaria. Two randomized double-blind trials were conducted to examine the activity and tolerability of mefloquine alone and in combination with sulfadoxine/pyrimethamine (MSP). In one trial mefloquine was compared with chloroquine in 40 patients with Plasm...

L.N.oc Hung; Vries, P.J. de; L.T.i Diem Thuy; Bich Lien; H.P.i Long; Tran Nhu Hung; Nguyen Van Nam; Trinh Kim Anh; Kager, P.A., 1997: Single dose artemisinin-mefloquine versus mefloquine alone for uncomplicated falciparum malaria. A randomized, double-blind comparison was made between two different regimens for the treatment of uncomplicated Plasmodium falciparum malaria. One regimen consisted of a single oral dose of 500 mg artemisinin followed 2 h later by a single oral d...

Looareesuwan, S.; Vanijanonta, S.; Viravan, C.; Wilairatana, P.; Charoenlarp, P.; Andrial, M., 1994: Randomized trial of mefloquine alone and artesunate followed by mefloquine for the treatment of acute uncomplicated falciparum malaria. Mefloquine is the main antimalarial used for treatment of falciparum malaria patients at the malaria clinics in Thailand. However, the cure rate with mefloquine alone has declined seriously in recent years. The efficacy and tolerability of a seque...

Bunnag, D.; Kanda, T.; Karbwang, J.; Thimasarn, K.; Pungpak, S.; Harinasuta, T., 1998: Two doses of artemether/mefloquine or artesunate/mefloquine combination for multidrug resistant falciparum Malaria. Plasmodium falciparum in Southeast Asia is highly resistant to chloroquine, sulfadoxine/ pyrimethamine, quinine and even mefloquine. The use of two doses of short course artemether/mefloquine combination has been shown to be effective in a recent...

Gutman, J.; Green, M.; Durand, S.; Rojas, O.Villalva.; Ganguly, B.; Quezada, W.Marquiño.; Utz, G.C.; Slutsker, L.; Ruebush, T.K.; Bacon, D.J., 2009: Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria. Artemisinin-based combination therapy (ACT) is recommended as a means of prolonging the effectiveness of first-line malaria treatment regimens. Different brands of mefloquine (MQ) have been reported to be non-bioequivalent; this could result in su...

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Tripathi, R.; Awasthi, A.; Dutta, G.P., 2005: Mefloquine resistance reversal action of ketoconazole - a cytochrome P450 inhibitor, against mefloquine-resistant malaria. Plasmodium knowlesi (W1) shows a high level of innate resistance to mefloquine as shown by recrudescence of blood-induced infection in rhesus monkeys, following oral mefloquine treatment with up to 80-160 mg/kg total dose over 3-4 days. Ketoconazo...

Bukirwa, H.; Orton, L., 2005: Artesunate plus mefloquine versus mefloquine for treating uncomplicated malaria. Multiple-drug-resistant malaria is widespread, and in South-East Asia resistance is high against nearly all single therapy antimalarial drugs. Here, and in other areas with low malaria transmission, the combination of artesunate and mefloquine may...

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