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Mammary ductal epithelial cell hyperproliferation and hyperplasia induced by a nutritional stress diet containing four components of a western-style diet

, : Mammary ductal epithelial cell hyperproliferation and hyperplasia induced by a nutritional stress diet containing four components of a western-style diet. Carcinogenesis 15(11): 2645-2648

We have studied effects of several nutrients on the proliferation of mammary ductal epithelial cells in C57BL/6J virgin female mice, using morphometry and (3H)dT in vivo labeling. A nutritional stress diet was given based on the AIN-76A semi-synthetic diet modified to contain four significant risk factors of a Western-style diet: high fat and phosphate and decreased calcium and vitamin D. The numbers of large, intermediate and terminal ducts and proliferating epithelial cells in mammary glands were assayed in control and stress diet groups. An increased number of mammary ducts and increased number of proliferating cells were found at the level of the small terminal ducts, a cancer-prone region in the mammary gland in the stress diet group compared to the control group after 20 weeks of diet administration. Thus, mammary terminal ductal hyperproliferation, expansion in the size of the proliferative epithelial cell compartment and excessive duplication of mammary ductal epithelial cells were found after this Western-style diet containing decreased dietary calcium and vitamin D. These changes are similar to those developing in colonic epithelium of mice maintained on the same diets and during chemically induced colonic carcinogenesis.

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Accession: 002889597

PMID: 7955119

DOI: 10.1093/carcin/15.11.2645

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Other references

Aleshin B.V., 1970: Reactions of the neuro secretory nuclei of the anterior hypothalamus on some nervous and hormonal actions. Arkhiv Anatomii Gistologii i Embriologii 58(3): 15-21

Kaminski, K. Z., 1977: Alonopsis ambigua cladocera in poland. In plankton collected in the ponds of Okret and Mlogoszyn, a rare species of Cladocera, A. ambigua, was observed. Some morphological features, the environment and general distribution of the species in Poland and Europe were discussed.

You, J.; Zong, W.; Li, X.; Ning, J.; Hu, H.; Li, X.; Xiao, J.; Xiong, L., 2013: The SNAC1-targeted gene OsSRO1c modulates stomatal closure and oxidative stress tolerance by regulating hydrogen peroxide in rice. Abiotic stresses such as drought cause a reduction of plant growth and loss of crop yield. Stomatal aperture controls CO<SUB>2</SUB> uptake and water loss to the atmosphere, thus playing important roles in both the yield gain and droug...

Cai, Bing; Loucks, Orie L., 1995: Responses of stage-structured population models for the earthworm, Eisenia foetida, to pH. Bulletin of the Ecological Society of America 76(3 SUPPL ): 309

Newport, C. A.; Leach, J., 1959: A method for the application of change-in-grade factors to individual logs - an IBM 650 program. Presents a method of computing, for a given log, the total volume of surfaced dry lumber recoverable; the volume recoverable in each grade; value in any given situation; value per unit volume in dollars per 1000 bd. ft. Data required for programmi...

Nkamba,E.M.; Tilford,S.; Williams,S.A., 2008: Components of Health Promoting Schools in Ugandan primary schools a pilot study. Health Promoting Schools (HPSs) represent key settings through which health can be improved. The World Health Organisation (WHO) has provided component indicators but data on the degree of coverage of these key components of HPSs in many countries...

Ziehe, M.; Hattemer, H. H., 1987: Population genetic approach to pollution resistance. A theoretical analysis of the development of the genetic structure of populations after the appearance of resistance, with respect to the frequency of resistant individuals and alleles conferring resistance, and population size. It is shown that t...

Suzuki, K.; Yamada, K.; Teranishi, M.; Tadauchi, O., 1975: Preliminary study on the geographical distribution of color forms in chrysolina aurichalcea coleoptera chrysomelidae. The geographical distribution of 2 color forms, the cyaneus-form and the cupreous-form, in a chrysomelid beetle Chrysolina aurichalcea (Mannerheim) (Chrysomelinae) is preliminarily reported for 37 Japanese populations.

Anonymous, 1980: Crop drying and storage. A multi-bin drier temperature controller based on a programmable calculator and an automatic m.c. determination system were developed. Large round bales proved extremely difficult to dry satisfactorily so that their use is not recommended except i...

Querol, Jordi; Campos, Narciso; Imperial, Santiago; Boronat, Albert; Rodriguez Concepcion, Manuel, 2002: Functional analysis of the Arabidopsis thaliana GCPE protein involved in plastid isoprenoid biosynthesis. Plastid isoprenoids are synthesized via the 2-C-methyl-D-erythritol 4-phosphate pathway. A few years after its discovery, most of the Escherichia coli genes involved in the pathway have been identified, including gcpE. In this work, we have identi...