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Novel polyamine derivatives as potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase



Novel polyamine derivatives as potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase



Bioorganic & Medicinal Chemistry Letters 5(17): 1957-1960



The inhibiting effects of several spermidine and spermine derivatives on T. cruzi trypanotione reductase were assessed. Spermidine and spermine derivatives containing hydrophobic aromatic substituents were found to be competitive inhibitors of trypanothione reductase. The most effective compounds tested were N-1,N-8-bis(2-naphthylmethyl)spermidine, N-4,N-8-bis(2-naphthylmethyl)spermine and N-4,N-8-bis(3-phenylpropyl)spermine.

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Accession: 002907386

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DOI: 10.1016/0960-894x(95)00331-m


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