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Oxamniquine inhibits metabolism of caffeine, hexobarbitone and antipyrine in vivo in mice


, : Oxamniquine inhibits metabolism of caffeine, hexobarbitone and antipyrine in vivo in mice. African Journal of Health Sciences 3(3): 105-108

Inhibition of hepatic metabolism of caffeine (assessed from the expiration of 14CO2 resulting from N-demethylation of 14C-labelled caffeine), hexobarbitone (assessed from sleeping times) and antipyrine (assessed from the expiration of 14CO2 resulting from oxidation of 14C-labelled antipyrine) was studied in male GB-1 mice administered a single 50 mg/kg oral dose of the schistosomicidal drug oxamniquine.

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Accession: 002914047

PMID: 17451311

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