+ Translate

Oxidative metabolism in insulin-treated gestational diabetes mellitus

, : Oxidative metabolism in insulin-treated gestational diabetes mellitus. American Journal of Physiology 272(6 Pt 1): E1099-E1107

To investigate whether protein, carbohydrate, and fat metabolism was normalized in insulin-treated gestational diabetes mellitus (GDM), eight Hispanic women with GDM and eight healthy controls were studied at 32-36 wk of gestation and 6 wk postpartum. Net substrate utilization was measured using room respiration calorimetry. Exogenous substrate oxidation was determined by 13C recovered in breath CO-2 from 13C-labeled leucine, glucose, and Hiolein. Women with GDM had higher 24-h oxygen consumption, carbon dioxide production, total energy expenditure, and basal metabolic rates than controls due to larger body mass. Adjusted for weight or fat-free mass, total energy expenditure, basal metabolic rate, and basal and 24-h whole body net protein, carbohydrate, and fat utilization did not differ between insulin-treated GDM subjects and controls in pregnancy or postpartum. Oxidation of (13C)leucine and (13C)glucose did not differ by group or pregnancy status. Recovery of exogenously administered (13C)Hiolein, a biosynthetic triglyceride, as breath 13CO-2 was significantly lower in the GDM group antepartum and postpartum (P = 0.02), indicating lower oxidation of exogenous triglycerides in GDM.

(PDF 0-2 workdays service)

Accession: 002914121

PMID: 9227457

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Descamps-Latscha, B.; Nguyen, A.T.; Feutren, G., 1990: Phagocyte oxidative metabolism in cyclosporine- or placebo-treated patients with insulin-dependent (type I) diabetes mellitus of recent onset. Several lines of evidence suggest that phagocyte-mediated oxidative processes are involved in damage to pancreatic islet cells of Type I insulin-dependent diabetes mellitus (IDDM). This hypothesis, however, has not yet been explored at the clinica...

Beyuo, T.; Obed, S.Amenyi.; Adjepong-Yamoah, K.Kweku.; Bugyei, K.Agyei.; Oppong, S.Antwi.; Marfoh, K., 2016: Metformin versus Insulin in the Management of Pre-Gestational Diabetes Mellitus in Pregnancy and Gestational Diabetes Mellitus at the Korle Bu Teaching Hospital: A Randomized Clinical Trial. To determine if metformin monotherapy or metformin in combination with insulin is equally effective as insulin monotherapy at glycemic control in diabetes mellitus in pregnancy among Ghanaians. This was a study involving 104 pregnant women with ty...

Shanbour K.A.; Thurnau G.R.; Minton V., 1991: Serum glucose insulin and c peptide levels in untreated and insulin treated pregnant women with gestational diabetes mellitus. American Journal of Obstetrics & Gynecology 164(1 PART 2): 281

D.C.anni, G.; Volpe, L.; Ghio, A.; Lencioni, C.; Cuccuru, I.; Benzi, L.; Del Prato, S., 2007: Maternal metabolic control and perinatal outcome in women with gestational diabetes mellitus treated with lispro or aspart insulin: comparison with regular insulin. Diabetes Care 30(4): E11-E11

Yang, J.Q.; Xu, Y.H.; Gai, M.Y., 1994: Breast-feeding in reducing regular insulin requirement in postpartum for insulin dependent diabetes mellitus and gestational diabetes mellitus. From Jan. 1987-Jun. 1993, 37 cases of insulin dependent diabetes mellitus (IDDM) pregnant women and 10 gestational diabetes mellitus (GDM) mothers requiring regular insulin (RI) treatment during pregnancy were recruited. A comparative study of the...

Kalkman, D.N.; Woudstra, P.; den Heijer, P.; Menown, I.B.A.; Erglis, A.; Suryapranata, H.; Arkenbout, K.E.; Iñiguez, Aés.; van 't Hof, A.W.J.; Muller, P.; Tijssen, J.G.; de Winter, R.J., 2016: One year clinical outcomes in patients with insulin-treated diabetes mellitus and non-insulin-treated diabetes mellitus compared to non-diabetics after deployment of the bio-engineered COMBO stent. The COMBO stent is a novel sirolimus-eluting stent with a luminal anti-CD34+ antibody layer to promote vessel healing. No data is currently available on clinical outcomes after treatment with this novel bio-engineered device in diabetic patients....

Stenninger, E.; Schollin, J.; Aman, J., 1991: Neonatal macrosomia and hypoglycaemia in children of mothers with insulin-treated gestational diabetes mellitus. All newborn children to mothers with gestational diabetes mellitus (GDM) in the county of Orebro were investigated during a one year prospective study. Neonatal macrosomia (birthweight greater than 3 SD) was observed in 27% of children of mothers...

Butte, N.F.; Hsu, H.W.; Thotathuchery, M.; Wong, W.W.; Khoury, J.; Reeds, P., 1999: Protein metabolism in insulin-treated gestational diabetes. To test the hypothesis that protein metabolism is not totally normalized in insulin treated gestational diabetes mellitus (GDM) patients compared with normal, pregnant control subjects. Protein metabolism in eight Hispanic women with insulin-treat...

Silva, I.dos.Santos.; Higgins, C.; Swerdlow, A.J.; Laing, S.P.; Slater, S.D.; Pearson, D.W.M.; Morris, A.D., 2005: Birthweight and other pregnancy outcomes in a cohort of women with pre-gestational insulin-treated diabetes mellitus, Scotland, 1979-95. To assess pregnancy outcomes, in particular birthweight, in a large population-based cohort of women in Scotland with pre-gestational insulin-treated diabetes mellitus. Data about diabetes from the Diabetes UK cohort were linked to data on births...

Dubé, E.; Ethier-Chiasson, M.; Lafond, J., 2013: Modulation of cholesterol transport by insulin-treated gestational diabetes mellitus in human full-term placenta. Gestational diabetes mellitus (GDM) is a common complication of pregnancy that is characterized by glucose intolerance, leads to dyslipidemia, and is aggravated by obesity. Cholesterol is taken up by the placenta as part of lipoproteins through th...