EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Oxidized low density lipoproteins in atherogenesis: role of dietary modification


, : Oxidized low density lipoproteins in atherogenesis: role of dietary modification. Annual Review of Nutrition 16: 51-71

The development of atherosclerosis is a complex and multistep process. There are many determinants in the pathogenesis of this condition, with different factors presumably playing key roles at different times in the evolution of the atherosclerotic plaque. It has been suggested that oxidation of low density lipoproteins (LDL) by cells in the artery wall leads to a proatherogenic particle that may help initiate early lesion formation. For this reason, understanding the determinants of LDL susceptibility to oxidation is essential for developing therapeutic strategies to inhibit this process. Oxidation of LDL begins with the abstraction of hydrogen from polyunsaturated fatty acids; thus, LDL fatty acid composition undoubtedly contributes to the process of LDL oxidation. Since dietary fatty acids influence the fatty acid composition of LDL and cell membranes, the amount and type of fat in the diet may effect susceptibility of LDL and cells to oxidative damage. Additionally, since cell membrane fatty acid composition also influences cellular formation of reactive oxygen species, dietary fatty acids may help determine the prooxidant activity of artery wall cells. Both cells and lipoproteins contain a variety of antioxidants that provide protection against oxidative stress. A major source of these antioxidants is the diet. Enrichment of the diet with foods high in such antioxidants as vitamin E, beta-carotene, or vitamin C, or supplementation of the diet with antioxidant vitamins, may inhibit oxidation and the process of atherosclerosis.


Accession: 002914160

PMID: 8839919

DOI: 10.1146/annurev.nu.16.070196.000411

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Yoshida, H., 2010: Front line of oxidized lipoproteins: role of oxidized lipoproteins in atherogenesis and cardiovascular disease risk. Ever since oxidized low density lipoprotein (LDL) was first identified in human atherosclerotic lesions, probucol was found to suppress the development of atherosclerosis in animals, and LDL incubated with vascular cells underwent oxidative modifi...

Mehta, J.L.; Bryant, J.L.; Mehta, P., 1995: Reduction of nitric oxide synthase activity in human neutrophils by oxidized low-density lipoproteins. Reversal of the effect of oxidized low-density lipoproteins by high-density lipoproteins and L-arginine. Oxidized low-density lipoproteins (ox-LDL) inhibit vascular relaxation by decreasing the synthesis or rapid degradation of endothelium-derived relaxing factor (EDRF), now identified to be nitric oxide (NO). We examined the regulation of NO synthas...

Weisser, B.; Locher, R.; Mengden, T.; Sachinidis, A.; Vetter, W., 1992: Oxidized low-density lipoproteins in atherogenesis: possible mechanisms of action. The increased atherogenic potential of oxidized low-density lipoprotein (ox-LDL) is well documented. In the present study, we investigated possible mechanisms of action of the difference to native LDL. In vitro oxidation of LDL was determined by m...

Pawłowicz, P.; Wilczyński, J.; Stachowiak, G.; Hincz, P., 2000: Administration of natural anthocyanins derived from chokeberry retardation of idiopathic and preeclamptic origin. Influence on metabolism of plasma oxidized lipoproteins: the role of autoantibodies to oxidized low density lipoproteins. To determinate the influence of anthocyanins from chokeberry on the generation of autoantibodies to oxidized low density lipoproteins (oLAB) in pregnancies complicated by intrauterine growth retardation (IUGR). Study group consisted of 105 pregnan...

Berliner, J.A.; Heinecke, J.W., 1996: The role of oxidized lipoproteins in atherogenesis. This article reviews our current understanding of the mechanisms of low-density lipoprotein (LDL) oxidation and the potential role of oxidized lipoproteins in atherosclerosis. Studies in hypercholesterolemic animal models indicate that oxidation o...

Turquieh, F.; Weyrich, A.S.; Castro Faria Neto, H.; Heery, J.M.; Zimmerman, G.A.; Mcintyre, T.M.; Prescott, S.M., 1995: Platelet-activating factor-like lipids in oxidized low density lipoproteins Pleiotropic mediators of atherogenesis. Circulation 92(8 SUPPL ): I288

Chen, H-Wen.; Kuo, C-Ling.; Huang, C-Shan.; Kuo, S-Jen.; Liu, C-San., 2007: Oxidized low-density lipoproteins, autoantibodies against oxidized low-density lipoproteins and carotid intima media thickness in a clinically healthy population. Background: Oxidized low-density lipoproteins (oxLDLs) play an important role in the progress of atherosclerosis. Autoantibodies (oxLDL Ab) against oxLDLs may reflect the extent of LDL oxidation in vivo. Our aim was to investigate the correlation...

Diakowska, D.; Grabowski, K.; Nienartowicz, Mław.; Zarębski, Pł.; Fudalej, K.; Markocka-Mączka, K., 2015: Circulating Oxidized Low-Density Lipoproteins and Antibodies against Oxidized Low-Density Lipoproteins as Potential Biomarkers of Colorectal Cancer. Introduction. The aim of the study was evaluation of the diagnostic utility of serum oxidized low-density lipoproteins (oxLDL), antibodies against oxLDLs (o-LAB), and CEA as risk markers of colorectal cancer (CRC). Material and Methods. The serum...

Eder, K.; Keller, U.; Brandsch, C., 2004: Effects of a dietary oxidized fat on cholesterol in plasma and lipoproteins and the susceptibility of low-density lipoproteins to lipid peroxidation in guinea pigs fed diets with different concentrations of vitamins E and C. To investigate the effect of a dietary oxidized fat on the concentrations of cholesterol in liver, plasma, and lipoproteins and the susceptibility of low-density lipoproteins (LDL) to lipid peroxidation, and to explore the effects of vitamins E an...

Meddings J.B.; Dietschy J.M., 1987: Low density lipoproteins and atherogenesis implications for modification through alterations in diet and new drug designs. Machleidt, H (Ed ) Contributions Of Chemistry to Health, Vol 2; Fifth Chemrawn (Chemical Research Applied to World Needs) Conference, Heidelberg, West Germany, September 22-26, 1986 Viii+403p Vch Publishers, Inc : New York, New York, Usa; Vch Verlagsgesellschaft Mbh: Weinheim, West Germany Illus Paper 269-282