EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Oxidized low density lipoproteins in atherogenesis: role of dietary modification


Annual Review of Nutrition 16: 51-71
Oxidized low density lipoproteins in atherogenesis: role of dietary modification
The development of atherosclerosis is a complex and multistep process. There are many determinants in the pathogenesis of this condition, with different factors presumably playing key roles at different times in the evolution of the atherosclerotic plaque. It has been suggested that oxidation of low density lipoproteins (LDL) by cells in the artery wall leads to a proatherogenic particle that may help initiate early lesion formation. For this reason, understanding the determinants of LDL susceptibility to oxidation is essential for developing therapeutic strategies to inhibit this process. Oxidation of LDL begins with the abstraction of hydrogen from polyunsaturated fatty acids; thus, LDL fatty acid composition undoubtedly contributes to the process of LDL oxidation. Since dietary fatty acids influence the fatty acid composition of LDL and cell membranes, the amount and type of fat in the diet may effect susceptibility of LDL and cells to oxidative damage. Additionally, since cell membrane fatty acid composition also influences cellular formation of reactive oxygen species, dietary fatty acids may help determine the prooxidant activity of artery wall cells. Both cells and lipoproteins contain a variety of antioxidants that provide protection against oxidative stress. A major source of these antioxidants is the diet. Enrichment of the diet with foods high in such antioxidants as vitamin E, beta-carotene, or vitamin C, or supplementation of the diet with antioxidant vitamins, may inhibit oxidation and the process of atherosclerosis.


Accession: 002914160

PMID: 8839919

DOI: 10.1146/annurev.nu.16.070196.000411



Related references

Front line of oxidized lipoproteins: role of oxidized lipoproteins in atherogenesis and cardiovascular disease risk. Rinsho Byori. Japanese Journal of Clinical Pathology 58(6): 622-630, 2010

Reduction of nitric oxide synthase activity in human neutrophils by oxidized low-density lipoproteins. Reversal of the effect of oxidized low-density lipoproteins by high-density lipoproteins and L-arginine. Biochemical Pharmacology 50(8): 1181-1185, 1995

Oxidized low-density lipoproteins in atherogenesis: possible mechanisms of action. Journal of Cardiovascular Pharmacology 19 Suppl 2: S4-S7, 1992

Administration of natural anthocyanins derived from chokeberry retardation of idiopathic and preeclamptic origin. Influence on metabolism of plasma oxidized lipoproteins: the role of autoantibodies to oxidized low density lipoproteins. Ginekologia Polska 71(8): 848-853, 2000

The role of oxidized lipoproteins in atherogenesis. Free Radical Biology & Medicine 20(5): 707-727, 1996

Platelet-activating factor-like lipids in oxidized low density lipoproteins Pleiotropic mediators of atherogenesis. Circulation 92(8 SUPPL ): I288, 1995

Oxidized low-density lipoproteins, autoantibodies against oxidized low-density lipoproteins and carotid intima media thickness in a clinically healthy population. Cardiology 110(4): 252-259, 2007

Circulating Oxidized Low-Density Lipoproteins and Antibodies against Oxidized Low-Density Lipoproteins as Potential Biomarkers of Colorectal Cancer. Gastroenterology Research and Practice 2015: 146819-146819, 2015

Effects of a dietary oxidized fat on cholesterol in plasma and lipoproteins and the susceptibility of low-density lipoproteins to lipid peroxidation in guinea pigs fed diets with different concentrations of vitamins E and C. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 74(1): 11-20, 2004

Low density lipoproteins and atherogenesis implications for modification through alterations in diet and new drug designs. Machleidt, H (Ed ) Contributions Of Chemistry to Health, Vol 2; Fifth Chemrawn (Chemical Research Applied to World Needs) Conference, Heidelberg, West Germany, September 22-26, 1986 Viii+403p Vch Publishers, Inc : New York, New York, Usa; Vch Verlagsgesellschaft Mbh: Weinheim, West Germany Illus Paper 269-282, 1987