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Oxygen active species-scavenger properties of coumarins

, : Oxygen active species-scavenger properties of coumarins. Phytotherapy Research 10(Supplement 1): S75-S78

The activities of 19 plant-derived or synthesized coumarins as scavengers of free radicals were examined. Coumarins with an ortho-dihydroxy function lowered the concentration of superoxide radicals. Hydroxyl radical production was inhibited significantly by 4-hydroxycoumarin, fraxetin and 4-methyldaphnetin. Ortho-dihydroxylated coumarins inhibited lipid peroxidation to a similar extent as the reference compound.

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