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Oxygen-dependent leishmanicidal activity of stimulated macrophages


Molecular & Cellular Biochemistry 154(1): 23-29
Oxygen-dependent leishmanicidal activity of stimulated macrophages
Peritoneal macrophages pretreated with different stimulants were analysed and compared with their respective controls for their ability to kill intracellular pathogenic L. donovani, (MHOM/IN/1983/AG83) an isolate from Indian subcontinent. Stimulation of macrophages by zymosan showed a higher microbicidal activity as compared to that by PMA. A correlation between microbicidal activity of the macrophages and the parameters related to respiratory burst activity such as liberation of O-2-, production of H-2O-2 and consumption of O-2 was sought. All the parameters showed a decrease in case of infected macrophages in comparison to those of the non-infected ones. Thus, it is possible that the impairment of macrophage activation by intracellular Leishmania contributes to their survival in the toxic environment of the host.

Accession: 002914210

PMID: 8717413

DOI: 10.1007/bf00248457

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