EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Pancreatic abnormalities and AIDS related sclerosing cholangitis






Genitourinary Medicine 73(4): 271-273

Pancreatic abnormalities and AIDS related sclerosing cholangitis

Objectives: Biliary tract abnormalities are well recognised in AIDS, most frequently related to opportunistic infection with Cryptosporidium, Microsporidium, and cytomegalovirus. We noted a high frequency of pancreatic abnormalities associated with biliary tract disease. To define these further we reviewed the clinical and radiological features in these patients. Methods: Notes and radiographs were available from two centres for 83 HIV positive patients who had undergone endoscopic retrograde cholangiopancreatography for the investigation of cholestatic liver function tests or abdominal pain. Results: 56 patients had AIDS related sclerosing cholangitis (ARSC); 86% of these patients had epigastric or right upper quadrant pain and 52% had hepatomegaly. Of the patients with ARSC, 10 had papillary stenosis alone, 11 had intra- and extrahepatic sclerosing cholangitis alone, and 35 had a combination of the two. Ampullary biopsies performed in 24 patients confirmed an opportunistic infection in 16. In 15 patients, intraluminal polyps were noted on the cholangiogram. Pancreatograms were available in 34 of the 45 patients with papillary stenosis, in which 29 (81%) had associated pancreatic duct dilatation, often with associated features of chronic pancreatitis. In the remaining 27 patients, final diagnoses included drug induced liver disease, acalculous cholecystitis, gall bladder empyema, chronic B virus hepatitis, and alcoholic liver disease. Conclusion: Pancreatic abnormalities are commonly seen with ARSC and may be responsible for some of the pain not relieved by biliary sphincterotomy. The most frequent radiographic biliary abnormality is papillary stenosis combined with ductal sclerosis.

(PDF same-day service: $19.90)

Accession: 002914834

PMID: 9389948

DOI: 10.1136/sti.73.4.271



Related references

Can ERCP distinguish between AIDS-related cholangitis and primary sclerosing cholangitis?. Gastroenterology 116(4 PART 2): A23, April, 1999

Pancreatic ductal abnormalities in primary sclerosing cholangitis. American Journal of Gastroenterology 81(9): 886, 1986

IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis: do they belong to a spectrum of sclerosing pancreatitis?. American Journal of Surgical Pathology 28(9): 1193-1203, 2004

Reversible AIDS-related sclerosing cholangitis. Journal of Hepatology 23(2): 209-211, 1995

Cholangiocarcinoma and AIDS-related sclerosing cholangitis. Annals of Internal Medicine 132(12): 1006-1007, 2000

Extensive Metastatic Cholangiocarcinoma Associated With IgG4-Related Sclerosing Cholangitis Misdiagnosed as Isolated IgG4-Related Sclerosing Cholangitis: A Case Report and Literature Review. Medicine 94(45): E2052-E2052, 2016

Pathology and immunopathology of immunoglobulin G4-related sclerosing cholangitis: The latest addition to the sclerosing cholangitis family. Hepatology Research 37 Suppl 3: S478-S486, 2007

Development of a scoring system for differentiating IgG4-related sclerosing cholangitis from primary sclerosing cholangitis. Journal of Gastroenterology (): -, 2016

IgG4-related sclerosing cholangitis should be included as an exclusion criterion for the diagnosis of primary sclerosing cholangitis. American Journal of Gastroenterology 102(3): 691-692, 2007

Comparison of intraductal ultrasonography findings between primary sclerosing cholangitis and IgG4-related sclerosing cholangitis. Journal of Gastroenterology and Hepatology 30(6): 1104-1109, 2016