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Pancreatitis-associated protein I (PAP I), an acute phase protein induced by cytokines. Identification of two functional interleukin-6 response elements in the rat PAP I promoter region


, : Pancreatitis-associated protein I (PAP I), an acute phase protein induced by cytokines. Identification of two functional interleukin-6 response elements in the rat PAP I promoter region. Journal of Biological Chemistry 270(38): 22417-22421

The effects of several cytokines and dexamethasone on rat PAP I gene transcription were studied in the rat pancreatic acinar cell line AR-42J. Tumour necrosis factor alpha induced an increase in PAP I mRNA expression and interferon gamma caused an even greater increase in mRNA level. These stimulations were antagonized by dexamethasone. Interleukin-1 (IL-1), IL-6 or dexamethasone, and combinations of IL-1 with IL-6 or dexamethasone were ineffective in inducing PAP I expression.

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Accession: 002914854

PMID: 7545677

DOI: 10.1074/jbc.270.38.22417

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